INTRODUCTION: Cardiac transplantation remains the gold standard for end-stage cardiomyopathies and congenital heart defects in pediatric patients. OBJECTIVE: This study aims to report on 20 years of experience since the first case and evaluate our results. METHODS: We conducted a retrospective analysis of the database and outpatient follow-up. Between October 1992 and April 2012, 109 patients underwent 114 transplants. 51.8% of them being female. The age of patients ranged from 12 days to 21 years with a mean of 8.8±5.7 years and a median of 5.2 years. The underlying diagnosis was dilated cardiomyopathy in 61.5%, congenital heart disease in 26.6% and restrictive cardiomyopathy in 11.9%. All patients above 17 years old had congenital heart disease. RESULTS: Survival rate at 30 days, 1, 5, 10, 15, and 20 years were 90.4%, 81.3%, 70.9%, 60.5%, 44.4% and 26.7%, respectively. Mean cold ischemic time was 187.9 minutes and it did not correlate with mortality (P>0.05). Infectious complications and rejection episodes were the most common complications (P<0.0001), occurring, respectively, in 66% and 57.4% of the survivors after 10 years. There was no incidence of graft vascular disease and lymphoproliferative disease at year one, but they affected, respectively, 7.4% and 11% of patients within 10 years. CONCLUSION: Twenty-year pediatric heart transplant results at our institution were quite satisfactory and complication rates were acceptable.
INTRODUCTION: Cardiac transplantation remains the gold standard for end-stage cardiomyopathies and congenital heart defects in pediatric patients. OBJECTIVE: This study aims to report on 20 years of experience since the first case and evaluate our results. METHODS: We conducted a retrospective analysis of the database and outpatient follow-up. Between October 1992 and April 2012, 109 patients underwent 114 transplants. 51.8% of them being female. The age of patients ranged from 12 days to 21 years with a mean of 8.8±5.7 years and a median of 5.2 years. The underlying diagnosis was dilated cardiomyopathy in 61.5%, congenital heart disease in 26.6% and restrictive cardiomyopathy in 11.9%. All patients above 17 years old had congenital heart disease. RESULTS: Survival rate at 30 days, 1, 5, 10, 15, and 20 years were 90.4%, 81.3%, 70.9%, 60.5%, 44.4% and 26.7%, respectively. Mean cold ischemic time was 187.9 minutes and it did not correlate with mortality (P>0.05). Infectious complications and rejection episodes were the most common complications (P<0.0001), occurring, respectively, in 66% and 57.4% of the survivors after 10 years. There was no incidence of graft vascular disease and lymphoproliferative disease at year one, but they affected, respectively, 7.4% and 11% of patients within 10 years. CONCLUSION: Twenty-year pediatric heart transplant results at our institution were quite satisfactory and complication rates were acceptable.
Authors: Anne I Dipchand; Richard Kirk; Leah B Edwards; Anna Y Kucheryavaya; Christian Benden; Jason D Christie; Fabienne Dobbels; Lars H Lund; Axel O Rahmel; Roger D Yusen; Josef Stehlik Journal: J Heart Lung Transplant Date: 2013-10 Impact factor: 10.247
Authors: K C Branco; E Azeka; E Trindade; F R B Galas; L A Hajjar; L Benvenuti; A Riso; C Tanamati; J Penha; J O C Auler; M Jatene Journal: Transplant Proc Date: 2012-10 Impact factor: 1.066
Authors: E Azeka; M Barbero-Marcial; M Jatene; P R Camargo; J O Auler; E Atik; J A Ramires; M Ebaid Journal: Arq Bras Cardiol Date: 2000-03 Impact factor: 2.000
Authors: Alfred Asante-Korang; Jeffrey P Jacobs; Jeremy Ringewald; Jennifer Carapellucci; Kristin Rosenberg; Daniel McKenna; Jorge McCormack; Ivan Wilmot; Abigail Gjeldum; Mayra Lopez-Cepero; John Sleasman Journal: Cardiol Young Date: 2011-12 Impact factor: 1.093
Authors: David L S Morales; Christopher S D Almond; Robert D B Jaquiss; David N Rosenthal; David C Naftel; M Patricia Massicotte; Tilman Humpl; Mark W Turrentine; James S Tweddell; Gordon A Cohen; Robert Kroslowitz; Eric J Devaney; Charles E Canter; Francis Fynn-Thompson; Olaf Reinhartz; Michiaki Imamura; Nancy S Ghanayem; Holger Buchholz; Sarah Furness; Robert Mazor; Sanjiv K Gandhi; Charles D Fraser Journal: J Heart Lung Transplant Date: 2011-01 Impact factor: 10.247
Authors: Brian Feingold; Seo Young Park; Diane M Comer; Charity G Moore; Steven A Webber; Cindy L Bryce Journal: J Heart Lung Transplant Date: 2012-11-13 Impact factor: 10.247
Authors: Kirk R Kanter; Robert N Vincent; Alexandria M Berg; William T Mahle; Joseph M Forbess; Paul M Kirshbom Journal: Ann Thorac Surg Date: 2004-08 Impact factor: 4.330
Authors: Leonardo A Miana; Guilherme Viotto Rodrigues da Silva; Luiz Fernando Caneo; Aida Luisa Turquetto; Carla Tanamati; Gustavo Foronda; Maria Raquel Massoti; Juliano G Penha; Estela Azeka; Filomena R B G Galas; Fabio B Jatene; Marcelo B Jatene Journal: Braz J Cardiovasc Surg Date: 2018 May-Jun