PURPOSE: We present here a case of bilateral exudative retinal detachments in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia and describe the patient's response to induction chemotherapy and clinical course. METHODS: A retrospective case study with fundus photographs and optical coherence tomography. A 46-year-old woman presented with bilateral exudative retinal detachments. A systemic evaluation revealed acute lymphoblastic leukemia. RESULTS AND CONCLUSION: This is an exceptional case in that the exudative retinal change so closely parallels systemic response to remission and relapse in a hematologic malignancy, and suggests that the clinical course of exudative retinal change may be a legitimate proxy for efficacy-or failure-of systemic therapy.
PURPOSE: We present here a case of bilateral exudative retinal detachments in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia and describe the patient's response to induction chemotherapy and clinical course. METHODS: A retrospective case study with fundus photographs and optical coherence tomography. A 46-year-old woman presented with bilateral exudative retinal detachments. A systemic evaluation revealed acute lymphoblastic leukemia. RESULTS AND CONCLUSION: This is an exceptional case in that the exudative retinal change so closely parallels systemic response to remission and relapse in a hematologic malignancy, and suggests that the clinical course of exudative retinal change may be a legitimate proxy for efficacy-or failure-of systemic therapy.