Literature DB >> 25372154

Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease.

Yanli Tian1, Xueli Zhang, Yuyan Li, Timothy M Shoup, Xin Teng, David R Elmaleh, Anna Moore, Chongzhao Ran.   

Abstract

In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could efficiently label Aβ plaques and CAAs in AD mice.

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Year:  2014        PMID： 25372154      PMCID： PMC4617529          DOI： 10.1039/c4cc06029f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  28 in total

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Review 2.  Strategies, development, and pitfalls of therapeutic options for Alzheimer's disease.

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Journal:  J Alzheimers Dis       Date:  2012       Impact factor: 4.472

3.  Surface structure of amyloid-beta fibrils contributes to cytotoxicity.

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4.  A novel in vitro filter trap assay identifies tannic acid as an amyloid aggregation inducer for HET-s.

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5.  A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.

Authors:  Thorlakur Jonsson; Jasvinder K Atwal; Stacy Steinberg; Jon Snaedal; Palmi V Jonsson; Sigurbjorn Bjornsson; Hreinn Stefansson; Patrick Sulem; Daniel Gudbjartsson; Janice Maloney; Kwame Hoyte; Amy Gustafson; Yichin Liu; Yanmei Lu; Tushar Bhangale; Robert R Graham; Johanna Huttenlocher; Gyda Bjornsdottir; Ole A Andreassen; Erik G Jönsson; Aarno Palotie; Timothy W Behrens; Olafur T Magnusson; Augustine Kong; Unnur Thorsteinsdottir; Ryan J Watts; Kari Stefansson
Journal:  Nature       Date:  2012-08-02       Impact factor: 49.962

6.  Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's disease.

Authors:  Xueli Zhang; Yanli Tian; Zeng Li; Xiaoyu Tian; Hongbin Sun; Hong Liu; Anna Moore; Chongzhao Ran
Journal:  J Am Chem Soc       Date:  2013-10-25       Impact factor: 15.419

Review 7.  Development of positron emission tomography β-amyloid plaque imaging agents.

Authors:  Chester A Mathis; N Scott Mason; Brian J Lopresti; William E Klunk
Journal:  Semin Nucl Med       Date:  2012-11       Impact factor: 4.446

8.  Amyloid-β peptide (1-42) aggregation induced by copper ions under acidic conditions.

Authors:  Yannan Bin; Xia Li; Yonghui He; Shu Chen; Juan Xiang
Journal:  Acta Biochim Biophys Sin (Shanghai)       Date:  2013-06-06       Impact factor: 3.848

9.  Resolving controversies on the path to Alzheimer's therapeutics.

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Journal:  Nat Med       Date:  2011-09-07       Impact factor: 53.440

10.  Probing and trapping a sensitive conformation: amyloid-β fibrils, oligomers, and dimers.

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Journal:  J Alzheimers Dis       Date:  2012       Impact factor: 4.472
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  5 in total

1.  Acetylation of Aβ40 Alters Aggregation in the Presence and Absence of Lipid Membranes.

Authors:  Albert W Pilkington; Jane Schupp; Morgan Nyman; Stephen J Valentine; David M Smith; Justin Legleiter
Journal:  ACS Chem Neurosci       Date:  2019-12-27       Impact factor: 4.418

2.  Beneficial Effects of Cyclic Ether 2-Butoxytetrahydrofuran from Sea Cucumber Holothuria scabra against Aβ Aggregate Toxicity in Transgenic Caenorhabditis elegans and Potential Chemical Interaction.

Authors:  Taweesak Tangrodchanapong; Nilubon Sornkaew; Laphatrada Yurasakpong; Nakorn Niamnont; Chanin Nantasenamat; Prasert Sobhon; Krai Meemon
Journal:  Molecules       Date:  2021-04-11       Impact factor: 4.411

3.  Epitope alteration by small molecules and applications in drug discovery.

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Journal:  Chem Sci       Date:  2022-06-28       Impact factor: 9.969

Review 4.  Structure and Function of Alzheimer's Amyloid βeta Proteins from Monomer to Fibrils: A Mini Review.

Authors:  Nikhil Agrawal; Adam A Skelton
Journal:  Protein J       Date:  2019-08       Impact factor: 2.371

5.  Sodium-22-radiolabeled silica nanoparticles as new radiotracer for biomedical applications: in vivo positron emission tomography imaging, biodistribution, and biocompatibility.

Authors:  Achraf Al Faraj; Basem Alotaibi; Abjal Pasha Shaik; Khaled Z Shamma; Ibrahim Al Jammaz; Jürgen Gerl
Journal:  Int J Nanomedicine       Date:  2015-10-08
  5 in total

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