Tiegang Liu1, Jianhua Zhen1, He Yu1, Wang Zhang1, Xiaofei Li1, Guokai Lv1, Ghulam Murtaza2, Xiaohong Gu1. 1. Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chao Yang District, 100029 Beijing, P.R. China. 2. Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
Abstract
BACKGROUND AND OBJECTIVE: The aim of this article, was the definition, and targets of possible mechanisms of Yin lai Decoction by retrieving the herbals in the decoction and integrating information from multi-databases, which can be guidance for the followed experimental study. MATHERIALS AND METHODS: The information from multi-databases was integrated. RESULTS: In the study, we discovered 92 possible gene targets of Yin lai Decoction, 87% of which appeared in the targets of Flos Lonicerae, Fructus Forsythiae and Scutellaria baicalensis Georgi. The function of these targets focuses on the anti-infection and regulating immune system, and metabolism of the body. CONCLUSION: Yin lai Decoction may affect the process of metabolism, immune response and infection by impact on the 92 possible gene targets, then it can mitigate the damage caused by infection and promote the body to health. But the definite mechanisms must be explored by further experimental study.
BACKGROUND AND OBJECTIVE: The aim of this article, was the definition, and targets of possible mechanisms of Yin lai Decoction by retrieving the herbals in the decoction and integrating information from multi-databases, which can be guidance for the followed experimental study. MATHERIALS AND METHODS: The information from multi-databases was integrated. RESULTS: In the study, we discovered 92 possible gene targets of Yin lai Decoction, 87% of which appeared in the targets of Flos Lonicerae, Fructus Forsythiae and Scutellaria baicalensis Georgi. The function of these targets focuses on the anti-infection and regulating immune system, and metabolism of the body. CONCLUSION: Yin lai Decoction may affect the process of metabolism, immune response and infection by impact on the 92 possible gene targets, then it can mitigate the damage caused by infection and promote the body to health. But the definite mechanisms must be explored by further experimental study.
Entities:
Keywords:
Gene targets; Immune response; Infection; Metabolism; Yin lai Decoction
Authors: Hao Ye; Li Ye; Hong Kang; Duanfeng Zhang; Lin Tao; Kailin Tang; Xueping Liu; Ruixin Zhu; Qi Liu; Y Z Chen; Yixue Li; Zhiwei Cao Journal: Nucleic Acids Res Date: 2010-11-21 Impact factor: 16.971
Authors: Da Wei Huang; Brad T Sherman; Qina Tan; Joseph Kir; David Liu; David Bryant; Yongjian Guo; Robert Stephens; Michael W Baseler; H Clifford Lane; Richard A Lempicki Journal: Nucleic Acids Res Date: 2007-06-18 Impact factor: 16.971