Literature DB >> 25371188

Artemether-lumefantrine compared to atovaquone-proguanil as a treatment for uncomplicated Plasmodium falciparum malaria in travelers.

Shirly Grynberg1, Tamar Lachish1, Eran Kopel1, Eyal Meltzer1, Eli Schwartz2.   

Abstract

Atovaquone-proguanil (AP) and artemether-lumefantrine (AL) are both treatments for uncomplicated Plasmodium falciparum malaria, but comparative clinical trials are lacking. We performed a retrospective analysis, comparing treatment failure and fever clearance time in non-immune travelers with uncomplicated P. falciparum malaria, treated with AP or AL. Sixty-nine patients were included during 2001-2013: 44 in the AP group and 25 in the AL group. Treatment failure was observed in 6 of 44 (13.6%) and 1 of 25 (4.0%) patients in the AP and AL groups, respectively. Six treatment failures were observed in travelers from West Africa. Fever clearance time was 44 ± 23 h in AL group versus 77 ± 28 h in AP group, (P < 0.001). Hospitalization time was significantly shorter in the AL group; 3.8 + 1.3 versus 5.1 + 2.8 days in the AP group (P = 0.04) In conclusion, travelers with uncomplicated P. falciparum malaria recover faster on AL than on AP. The AL should probably be the drug of choice for this population. © The American Society of Tropical Medicine and Hygiene.

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Year:  2014        PMID： 25371188      PMCID： PMC4347368          DOI： 10.4269/ajtmh.14-0249

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  18 in total

1.  Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa.

Authors:  Eli Schwartz; Shay Bujanover; Kevin C Kain
Journal:  Clin Infect Dis       Date:  2003-07-18       Impact factor: 9.079

2.  Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia.

Authors:  Mey Bouth Denis; Reiko Tsuyuoka; Pharath Lim; Niklas Lindegardh; Poravuth Yi; Sophoan Narann Top; Duong Socheat; Thierry Fandeur; Anna Annerberg; Eva Maria Christophel; Pascal Ringwald
Journal:  Trop Med Int Health       Date:  2006-12       Impact factor: 2.622

3.  Atovaquone plus proguanil versus halofantrine for the treatment of imported acute uncomplicated Plasmodium falciparum malaria in non-immune adults: a randomized comparative trial.

Authors:  O Bouchaud; E Monlun; K Muanza; A Fontanet; T Scott; A Goetschel; J D Chulay; J Le Bras; M Danis; M Le Bras; J P Coulaud; M Gentilini
Journal:  Am J Trop Med Hyg       Date:  2000 Nov-Dec       Impact factor: 2.345

4.  Efficacy and safety of atovaquone-proguanil compared with mefloquine in the treatment of nonimmune patients with uncomplicated P. falciparum malaria in Japan.

Authors:  Akihiro Hitani; Tetsuya Nakamura; Hiroshi Ohtomo; Yukifumi Nawa; Mikio Kimura
Journal:  J Infect Chemother       Date:  2006-11-06       Impact factor: 2.211

5.  Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria.

Authors:  Quinton L Fivelman; Geoffrey A Butcher; Ipemida S Adagu; David C Warhurst; Geoffrey Pasvol
Journal:  Malar J       Date:  2002-02-08       Impact factor: 2.979

6.  Artemisinin resistance in Cambodia: a clinical trial designed to address an emerging problem in Southeast Asia.

Authors:  Harald Noedl; Youry Se; Sabaithip Sriwichai; Kurt Schaecher; Paktiya Teja-Isavadharm; Bryan Smith; Wiriya Rutvisuttinunt; Delia Bethell; Sittidech Surasri; Mark M Fukuda; Duong Socheat; Lon Chan Thap
Journal:  Clin Infect Dis       Date:  2010-10-28       Impact factor: 9.079

7.  First case of treatment failure of artemether-lumefantrine in a Japanese traveler with imported falciparum malaria.

Authors:  Yasutaka Mizuno; Yasuyuki Kato; Koichiro Kudo; Shigeyuki Kano
Journal:  Jpn J Infect Dis       Date:  2009-03       Impact factor: 1.362

8.  Therapy of uncomplicated falciparum malaria in Europe: MALTHER - a prospective observational multicentre study.

Authors:  Olivier Bouchaud; Nikolai Mühlberger; Philippe Parola; Guido Calleri; Alberto Matteelli; Gabriele Peyerl-Hoffmann; Frédéric Méchaï; Philippe Gautret; Jan Clerinx; Peter G Kremsner; Tomas Jelinek; Annette Kaiser; Anna Beltrame; Matthias L Schmid; Peter Kern; Meike Probst; Alessandro Bartoloni; Thomas Weinke; Martin P Grobusch
Journal:  Malar J       Date:  2012-06-22       Impact factor: 2.979

9.  Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial.

Authors:  Arjen M Dondorp; Caterina I Fanello; Ilse C E Hendriksen; Ermelinda Gomes; Amir Seni; Kajal D Chhaganlal; Kalifa Bojang; Rasaq Olaosebikan; Nkechinyere Anunobi; Kathryn Maitland; Esther Kivaya; Tsiri Agbenyega; Samuel Blay Nguah; Jennifer Evans; Samwel Gesase; Catherine Kahabuka; George Mtove; Behzad Nadjm; Jacqueline Deen; Juliet Mwanga-Amumpaire; Margaret Nansumba; Corine Karema; Noella Umulisa; Aline Uwimana; Olugbenga A Mokuolu; Olanrewaju T Adedoyin; Wahab B R Johnson; Antoinette K Tshefu; Marie A Onyamboko; Tharisara Sakulthaew; Wirichada Pan Ngum; Kamolrat Silamut; Kasia Stepniewska; Charles J Woodrow; Delia Bethell; Bridget Wills; Martina Oneko; Tim E Peto; Lorenz von Seidlein; Nicholas P J Day; Nicholas J White
Journal:  Lancet       Date:  2010-11-07       Impact factor: 79.321

10.  Severe atovaquone-resistant Plasmodium falciparum malaria in a Canadian traveller returned from the Indian subcontinent.

Authors:  Thomas L Perry; Prativa Pandey; Jennifer M Grant; Kevin C Kain
Journal:  Open Med       Date:  2009-01-20
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  3 in total

1.  Clinical implications of Plasmodium resistance to atovaquone/proguanil: a systematic review and meta-analysis.

Authors:  Henry M Staines; Rebekah Burrow; Beatrix Huei-Yi Teo; Irina Chis Ster; Peter G Kremsner; Sanjeev Krishna
Journal:  J Antimicrob Chemother       Date:  2018-03-01       Impact factor: 5.790

Review 2.  Are national treatment guidelines for falciparum malaria in line with WHO recommendations and is antimalarial resistance taken into consideration? - A review of guidelines in non-endemic countries.

Authors:  Marc T Visser; Rens Zonneveld; Thomas J Peto; Michele van Vugt; Arjen M Dondorp; Rob W van der Pluijm
Journal:  Trop Med Int Health       Date:  2022-01-13       Impact factor: 3.918

3.  Early Economic Evaluation to Identify the Necessary Test Characteristics of a New Typhoid Test to be Cost Effective in Ghana.

Authors:  Samuel N Frempong; Andrew J Sutton; Clare Davenport; Pelham Barton
Journal:  Pharmacoecon Open       Date:  2020-03
  3 in total

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