Literature DB >> 25370790

Novel naphthoquinone derivatives and evaluation of their trypanocidal and leishmanicidal activities.

Aline Alves dos Santos Naujorks1, Adriano Olímpio da Silva, Rosangela da Silva Lopes, Sérgio de Albuquerque, Adilson Beatriz, Maria Rita Marques, Dênis Pires de Lima.   

Abstract

Herein, we report the synthesis of 12 new naphthoquinone derivatives, 6 substituted 1,4-naphthoquinones and 6 heterocycle-fused naphthoquinones, as well as evaluation of their trypanocidal and leishmanicidal activities. Compounds 11a and 13a were active against the amastigote stage of T. cruzi and showed low cytotoxic effects. With respect to leishmanicidal assays, all compounds were inactive against the promastigote stages of L. chagasi and L. braziliensis.

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Year:  2014        PMID： 25370790     DOI： 10.1039/c4ob01869a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  4 in total

1.  In Silico Antiprotozoal Evaluation of 1,4-Naphthoquinone Derivatives against Chagas and Leishmaniasis Diseases Using QSAR, Molecular Docking, and ADME Approaches.

Authors:  Lina S Prieto Cárdenas; Karen A Arias Soler; Diana L Nossa González; Wilson E Rozo Núñez; Agobardo Cárdenas-Chaparro; Pablo R Duchowicz; Jovanny A Gómez Castaño
Journal:  Pharmaceuticals (Basel)       Date:  2022-05-31

2.  Novel Solid Dispersions of Naphthoquinone Using Different Polymers for Improvement of Antichagasic Activity.

Authors:  Verônica da Silva Oliveira; Elen Diana Dantas; Anna Thereza de Sousa Queiroz; Johny Wysllas de Freitas Oliveira; Marcelo de Sousa da Silva; Patricia Garcia Ferreira; Fernando de Carvalho da Siva; Vitor Francisco Ferreira; Ádley Antonini Neves de Lima
Journal:  Pharmaceutics       Date:  2020-11-24       Impact factor: 6.321

3.  A photochemical and theoretical study of the triplet reactivity of furano- and pyrano-1,4-naphthoquionones towards tyrosine and tryptophan derivatives.

Authors:  Rodolfo I Teixeira; Juliana S Goulart; Rodrigo J Corrêa; Simon J Garden; Sabrina B Ferreira; José Carlos Netto-Ferreira; Vitor F Ferreira; Paula Miro; M Luisa Marin; Miguel A Miranda; Nanci C de Lucas
Journal:  RSC Adv       Date:  2019-04-30       Impact factor: 4.036

4.  Characterization and Trypanocidal Activity of a Novel Pyranaphthoquinone.

Authors:  Elen Diana Dantas; Fabia Julliana Jorge de Souza; William Nascimento Litaiff Nogueira; Cláudia Cândida Silva; Pedro Henrique Antunes de Azevedo; Cícero Flávio Soares Aragão; Patricia Danielle Oliveira de Almeida; Mariana Filomena do Carmo Cardoso; Fernando de Carvalho da Silva; Eduardo Pereira de Azevedo; Euzébio Guimarães Barbosa; Emerson Silva Lima; Vitor Francisco Ferreira; Ádley Antonini Neves de Lima
Journal:  Molecules       Date:  2017-09-30       Impact factor: 4.411
  4 in total

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