Literature DB >> 25370127

Diketopyrrolopyrrole-porphyrin conjugates with high two-photon absorption and singlet oxygen generation for two-photon photodynamic therapy.

Julie Schmitt1, Valérie Heitz, Angélique Sour, Frédéric Bolze, Hussein Ftouni, Jean-Francois Nicoud, Lucia Flamigni, Barbara Ventura.   

Abstract

Two-photon photodynamic therapy is a promising therapeutic method which requires the development of sensitizers with efficient two-photon absorption and singlet-oxygen generation. Reported here are two new diketopyrrolopyrrole-porphyrin conjugates as robust two-photon absorbing dyes with high two-photon absorption cross-sections within the therapeutic window. Furthermore, for the first time the singlet-oxygen generation efficiency of diketopyrrolopyrrole-containing systems is investigated. A preliminary study on cell culture showed efficient two-photon induced phototoxicity.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  diketopyrroles; dyes/pigments; photodynamic therapy; porphyrins; singlet oxygen; two-photon absorption

Mesh：

Substances：

Year:  2014        PMID： 25370127     DOI： 10.1002/anie.201407537

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  20 in total

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6.  Spatial and Temporal Resolution of the Oxygen-Independent Photoinduced DNA Interstrand Cross-Linking by a Nitroimidazole Derivative.

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Review 8.  Beyond the Barriers of Light Penetration: Strategies, Perspectives and Possibilities for Photodynamic Therapy.

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Journal:  Angew Chem Int Ed Engl       Date:  2017-10-19       Impact factor: 15.336

10.  Metal Complexes for Two-Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-Photon Photosensitization of Cancer Cells under Near-IR Light.

Authors:  Luke K McKenzie; Igor V Sazanovich; Elizabeth Baggaley; Mickaële Bonneau; Véronique Guerchais; J A Gareth Williams; Julia A Weinstein; Helen E Bryant
Journal:  Chemistry       Date:  2016-11-02       Impact factor: 5.236
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