| Literature DB >> 25369455 |
Ahmadou M Jingi1, Jean Jacques N Noubiap2, Arnold Ewane Onana3, Jobert Richie N Nansseu4, Binhuan Wang5, Samuel Kingue1, André Pascal Kengne6.
Abstract
OBJECTIVE: To assess the availability and affordability of medicines and routine tests for cardiovascular disease (CVD) and diabetes in the West region of Cameroon, a low-income setting.Entities:
Mesh:
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Year: 2014 PMID: 25369455 PMCID: PMC4219782 DOI: 10.1371/journal.pone.0111812
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Availability of medicines and test per site and the population served.
| Survey site | Area | Population served2012 estimates | Availability ofMedicines | Availability of WHOrecommended tests | Availability ofall tests |
| Foumban | Urban | 170,571 | 36.4% | 83.3% | 91.7% |
| Dschang | Urban | 211,818 | 45.5% | 100% | 100.0% |
| Mifi | Urban | 254,123 | 59.1% | 66.7% | 58.3% |
| Foumbot | Rural | 59,223 | 45.5% | 66.7% | 50.0% |
| Bangourain | Rural | 29,694 | 50.0% | 33.3% | 25.0% |
| Balessing | Rural | NA | 18.2% | 50.0% | 41.7% |
| Penka Michel | Rural | 88,338 | 22.7% | 83.3% | 75.0% |
| Mbouda | Urban | 250,967 | 50.0% | 83.3% | 83.3% |
| Batcham | Rural | 90,271 | 9.1% | 50.0% | 41.7% |
| Salvia | Urban | NA | 100% | 16.7% | NA |
| Market | Urban | NA | 63.6% | NA | NA |
NA: Not Applicable.
Found in Penka-Michel health district.
Found in the Mifi health district.
Availability, affordability and median price of selected tests in the investigation of cardiovascular disease and diabetes.
| Test | Availability | Median price | Number of days' wage for investigation | |||
| Rural | Urban | All sites | Local (FCFA) | US Dollar | ||
| Glycaemia | 100% | 100% | 100% | 1,250 | 2.38 | 1.34 |
| Creatinemia | 80% | 100% | 80% | 3,000 | 5.72 | 3.21 |
| Urea | 80% | 100% | 80% | 3,000 | 5.72 | 3.21 |
| Total cholesterol | 20% | 75% | 40% | 3,350 | 6.39 | 3.59 |
| HDL cholesterol | 20% | 75% | 40% | 3,350 | 6.39 | 3.59 |
| Triglyceride | 20% | 75% | 40% | 2,850 | 5.43 | 3.05 |
| Proteinuria | 100% | 100% | 90% | 1,000 | 1.91 | 1.07 |
| Kaliemia | 40% | 100% | 60% | 3,000 | 5.72 | 3.21 |
| HbA1c | 0% | 50% | 20% | 11,750 | 22.40 | 12.58 |
| Uric acid | 0% | 100% | 40% | 3,100 | 5.91 | 3.32 |
| Full blood count | 80% | 100% | 80% | 3,750 | 7.15 | 4.02 |
| ECG | 0% | 25% | 10% | 10,000 | 19.07 | 10.7 |
Availability, affordability, median price and ratios of Medicines.
| Drug presentation | Availability | Median price (per tablet or vial) | Defineddaily dose | Cost of Dailytreatment (USD) | Cost of 30 days'treatment (USD) | Number of days'wage for 1 month | ||||||
| Rural | Urban | Reference(Pharmacy) | All sites | Local price(FCFA) | Local price(USD) | WHO price(USD) | Ratio | |||||
| Acetylsalicylic acid 500 mg | 40% | 100% | 100% | 70% | 5.0 | 0.01 | 0.0045 | 2.22 | 100 mg | 0.002 | 0.06 | 0.03 |
| Atenolol 50 mg | 0% | 0% | 100% | 10% | 78.1 | 0.15 | 0.0106 | 14.15 | 75 mg | 0.23 | 6.75 | 3.92 |
| Benzathine-benzylpenicilline2.4MIU | 100% | 100% | 100% | 100% | 210.0 | 0.40 | 0.3241 | 1.23 | 2MIU | 0.40 | 12.00 | 6.74 |
| Captopril 25 mg | 0% | 50% | 100% | 30% | 100.0 | 0.19 | 0.0216 | 9.80 | 50 mg | 0.38 | 11.40 | 6.41 |
| Ramipril 5 mg | 0% | 25% | 100% | 20% | 240.1 | 0.46 | NA | NA | 5 mg | 0.84 | 25.20 | 14.16 |
| Hydrochlorothiazide 50 mg | 20% | 50% | 100% | 40% | 10.0 | 0.02 | 0.0050 | 4.00 | 25 mg | 0.01 | 0.30 | 0.17 |
| Furosemide 40 mg | 100% | 100% | 100% | 100% | 5.0 | 0.01 | 0.0061 | 1.64 | 40 mg | 0.01 | 0.30 | 0.17 |
| Isosorbide dinitrate 5 mg | 0% | 0% | 100% | 10% | 81.6 | 0.16 | 0.0142 | 11.27 | 20 mg | 0.64 | 19.20 | 10.79 |
| Losartan 50 mg | 0% | 0% | 100% | 10% | 685.4 | 1.31 | 0.0185 | 70.81 | 50 mg | 0.76 | 22.80 | 12.81 |
| Simvastatin 20 mg | 0% | 0% | 100% | 10% | 295.0 | 0.56 | 0.0252 | 22.22 | 20 mg | 1.81 | 54.30 | 30.51 |
| Methyldopa 250 mg | 40% | 75% | 100% | 60% | 30.0 | 0.06 | 0.0295 | 2.03 | 1 g | 0.24 | 7.20 | 4.10 |
| Nifedipine 10 mg | 20% | 75% | 100% | 10% | 20.0 | 0.04 | 0.0130 | 3.08 | 30 mg | 0.12 | 3.60 | 2.02 |
| Nifedipine 20 mg SR | 0% | 25% | 100% | 20% | 42.3 | 0.08 | 0.0233 | 3.43 | 30 mg | 0.12 | 3.60 | 2.02 |
| Phenoxymethylpenincilline250 mg | 60% | 50% | 100% | 60% | 15.0 | 0.03 | 0.0158 | 1.90 | 3MIU | 0.18 | 5.40 | 3.03 |
| Propranolol 40 mg | 20% | 0% | 100% | 20% | 26.9 | 0.05 | 0.0059 | 8.47 | 160 mg | 0.20 | 6.00 | 3.37 |
| Spironolactone 50 mg | 0% | 0% | 100% | 10% | 156.7 | 0.30 | 0.0338 | 8.87 | 75 mg | 0.45 | 13.50 | 7.58 |
| Heparine 5000 UI | 0% | 0% | 100% | 10% | 2 835.0 | 5.41 | 0.9055 | 5.97 | 10000 IU | 10.82 | 324.60 | 182.36 |
| Glibenclamide 5 mg | 60% | 100% | 100% | 80% | 5.0 | 0.01 | 0.0042 | 2.38 | 10 mg | 0.02 | 0.60 | 0.34 |
| Metformine 500 mg | 60% | 100% | 100% | 80% | 7.5 | 0.01 | 0.0168 | 0.59 | 2 g | 0.04 | 1.20 | 0.67 |
| Actrapid 100 IU/ml | 60% | 100% | 100% | 80% | 3,000.0 | 5.72 | 0.7723 | 7.41 | 40 IU | 0.23 | 6.86 | 3.85 |
| Insulatard 100 IU/ml | 0% | 0% | 100% | 10% | 3,000.0 | 5.72 | 0.7723 | 7.41 | 40 IU | 0.23 | 6.86 | 3.85 |
| Mixtard 100 IU/ml | 60% | 100% | 100% | 80% | 14,500.0 | 27.65 | 0.6143 | 45.01 | 40 IU | 1.11 | 33.30 | 18.70 |
*Ratio: Local price/WHO price.
NA: Data not available in the 2012 edition.
Estimated costs of managing cardiovascular risk profile.
| Purpose | Components | Cost of tests(days’ wages) | Costs of drugs(days’ wages) | Total cost(days’ wages) | |
| Diagnosis and stratification | Absoluterisk | Minimal WHO recommended tests | 29.76 | NA | 29.76 |
| Primaryprevention | <10% Risk | Lifestyle changes and 12-monthly risk monitoring | 1.05 | NA | 1.05 |
| 10−20%Risk | Lifestyle changes and 6-monthly risk monitoring | 2.11 | NA | 2.11 | |
| 20−30%Risk | Statin/Antihypertensive/6-monthly risk monitoring | 2.11 | 30.67 | 32.78 | |
| ≥30%Risk | Statin/Antihypertensive/Acetylsalicylic acid/3-monthlyrisk monitoring | 4.22 | 30.70 | 34.92 | |
| Secondaryprevention | β-Blocker, ACEI, Statin, Acetylsalicylic acid/3-monthlyrisk monitoring | 4.22 | 37.11 | 41.33 |
Minimal WHO recommended tests include fasting blood sugar, cholesterol, potassium levels, proteinuria and ECG.
Risk monitoring includes lipid profile, fasting blood sugar and proteinuria. It cost 12.6 days’ wages. As this cumulates over the months, 12-monthly monitoring and 6-monthly monitoring cost 1.05 days’ wages and 2.11 days’ wages.
NA: not applicable.
WHO: World Health Organization; ACEI: Angiotensin Converting Enzyme Inhibitor.
Figure 1Comprehensive analysis of medicine availability and affordability.
The availability (%) each drug is depicted on the x-axis, while the y-axis shows the price (days’ wages).