A Rashidian1, A H Omidvari2, Y Vali3, S Mortaz4, R Yousefi-Nooraie5, M Jafari6, Z A Bhutta7. 1. Knowledge Utilization Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: arashidian@tums.ac.ir. 2. Knowledge Utilization Research Center, Tehran University of Medical Sciences, Tehran, Iran. 3. Knowledge Utilization Research Center, Tehran University of Medical Sciences, Tehran, Iran; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 4. Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Canada. 5. Health Research Methodology Program, Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada. 6. Health Management and Economics Research Center, School of Health Management and Information Sciences, Tehran University of Medical Sciences, Tehran, Iran; Department of Health Services Management, School of Health Management and Information Sciences, Tehran University of Medical Sciences, Tehran, Iran. 7. Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan.
Abstract
BACKGROUND: Several reports recommend the implementation of perinatal regionalization for improvements in maternal and neonatal outcomes, while research evidence on the effectiveness of perinatal regionalization has been limited. The interventional studies have been assessed for robust evidence on the effectiveness of perinatal regionalization on improving maternal and neonatal health outcomes. METHODS: Bibliographic databases of Medline, EMbase, EconLit, HMIC have been searched using sensitive search terms for interventional studies that reported important patient or process outcomes. At least two authors assessed eligibility for inclusion and the risk of biases and extracted data from the included studies. As meta-analysis was not possible, a narrative analysis as well as a 'vote-counting' analysis has been conducted for important outcomes. RESULTS: After initial screenings 53 full text papers were retrieved. Eight studies were included in the review from the USA, Canada and France. Studies varied in their designs, and in the specifications of the intervention and setting. Only three interrupted time series studies had a low risk of bias, of which only one study reported significant reductions in neonatal and infant mortality. Studies of higher risk of bias were more likely to report improvements in outcomes. CONCLUSIONS: Implementing perinatal regionalization programs is correlated with improvements in perinatal outcomes, but it is not possible to establish a causal link. Despite several high profile policy statements, evidence of effect is weak. It is necessary to assess the effectiveness of perinatal regionalization using robust research designs in a more diverse range of countries.
BACKGROUND: Several reports recommend the implementation of perinatal regionalization for improvements in maternal and neonatal outcomes, while research evidence on the effectiveness of perinatal regionalization has been limited. The interventional studies have been assessed for robust evidence on the effectiveness of perinatal regionalization on improving maternal and neonatal health outcomes. METHODS: Bibliographic databases of Medline, EMbase, EconLit, HMIC have been searched using sensitive search terms for interventional studies that reported important patient or process outcomes. At least two authors assessed eligibility for inclusion and the risk of biases and extracted data from the included studies. As meta-analysis was not possible, a narrative analysis as well as a 'vote-counting' analysis has been conducted for important outcomes. RESULTS: After initial screenings 53 full text papers were retrieved. Eight studies were included in the review from the USA, Canada and France. Studies varied in their designs, and in the specifications of the intervention and setting. Only three interrupted time series studies had a low risk of bias, of which only one study reported significant reductions in neonatal and infant mortality. Studies of higher risk of bias were more likely to report improvements in outcomes. CONCLUSIONS: Implementing perinatal regionalization programs is correlated with improvements in perinatal outcomes, but it is not possible to establish a causal link. Despite several high profile policy statements, evidence of effect is weak. It is necessary to assess the effectiveness of perinatal regionalization using robust research designs in a more diverse range of countries.
Authors: Katy B Kozhimannil; Michelle M Casey; Peiyin Hung; Shailendra Prasad; Ira S Moscovice Journal: Am J Obstet Gynecol Date: 2015-12-02 Impact factor: 8.661
Authors: Sarah N Kunz; Dmitry Dukhovny; Jochen Profit; Wenyang Mao; David Miedema; John A F Zupancic Journal: J Pediatr Date: 2018-10-02 Impact factor: 4.406
Authors: S N Kunz; J A F Zupancic; J Rigdon; C S Phibbs; H C Lee; J B Gould; J Leskovec; J Profit Journal: J Perinatol Date: 2017-03-23 Impact factor: 2.521
Authors: Sarah G Moxon; Hannah Blencowe; Patricia Bailey; John Bradley; Louise Tina Day; Pavani K Ram; Jean-Pierre Monet; Allisyn C Moran; Willibald Zeck; Joy E Lawn Journal: PLoS One Date: 2019-07-11 Impact factor: 3.240
Authors: Katherine R Iverson; Emma Svensson; Kristin Sonderman; Ernest J Barthélemy; Isabelle Citron; Kerry A Vaughan; Brittany L Powell; John G Meara; Mark G Shrime Journal: Int J Health Policy Manag Date: 2019-09-01