| Literature DB >> 25369113 |
Maria Manuela Rigano1, Assunta Raiola, Gian Carlo Tenore, Daria Maria Monti, Rita Del Giudice, Luigi Frusciante, Amalia Barone.
Abstract
Solanum lycopersicum represents an important source of antioxidants and other bioactive compounds. Previously two Solanum pennellii introgression lines (IL 7-3 and IL 12-4) were identified as carrying quantitative trait loci (QTL) increasing fruit ascorbic acid and phenolics content. Novel tomato lines were obtained by pyramiding these selected QTLs in the genetic background of the cultivated line M82. Pyramided lines revealed significant increases of total phenolics, phenolic acids, ascorbic acid, and total antioxidant activity compared to parental lines IL 7-3 and IL 12-4 and the cultivated line M82. In addition, tomato extracts obtained from the pyramided lines had no cytotoxic effect on normal human cells while exhibiting a selective cytotoxic effect on aggressive cancer cells. Therefore, the present study demonstrates that it is possible to incorporate favorable wild-species QTLs in the cultivated genetic background to obtain genotypes with higher nutritional value.Entities:
Keywords: MTT test; Solanum lycopersicum; antioxidant power; ascorbic acid; phenolic acid; phenolics
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Year: 2014 PMID： 25369113 DOI： 10.1021/jf502573n
Source DB: PubMed Journal: J Agric Food Chem ISSN： 0021-8561 Impact factor: 5.279