Daniel A Morris1, Masaaki Takeuchi2, Maximilian Krisper3, Clemens Köhncke3, Tarek Bekfani3, Tim Carstensen3, Sabine Hassfeld3, Marc Dorenkamp3, Kyoko Otani2, Kiyohiro Takigiku4, Chisato Izumi5, Satoshi Yuda6, Konomi Sakata7, Nobuyuki Ohte8, Kazuaki Tanabe9, Engin Osmanoglou10, York Kühnle3, Hans-Dirk Düngen3, Satoshi Nakatani11, Yutaka Otsuji2, Wilhelm Haverkamp3, Leif-Hendrik Boldt3. 1. Department of Cardiology, Charité University Hospital (Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin), Augustenburger Platz 1, 13353 Berlin, Germany daniel-armando.morris@charite.de. 2. School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. 3. Department of Cardiology, Charité University Hospital (Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin), Augustenburger Platz 1, 13353 Berlin, Germany. 4. Nagano Children's Hospital, Azumino, Japan. 5. Tenri Hospital, Tenri, Japan. 6. Sapporo Medical University School of Medicine, Sapporo, Japan. 7. Kyorin University School of Medicine, Tokyo, Japan. 8. Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. 9. Shimane University Faculty of Medicine, Izumo, Japan. 10. Meoclinic, Berlin, Germany. 11. Osaka University Graduate School of Medicine, Suita, Japan.
Abstract
AIMS: The aim of this multicentre study was to determine the normal range and the clinical relevance of the myocardial function of the left atrium (LA) analysed by 2D speckle-tracking echocardiography (2DSTE). METHODS AND RESULTS: We analysed 329 healthy adult subjects prospectively included in 10 centres and a validation group of 377 patients with left ventricular diastolic dysfunction (LVDD). LA myocardial function was analysed by LA strain rate peak during LA contraction (LA-SRa) and LA strain peak during LA relaxation (LA-Strain). The range of values of LA myocardial function in healthy subjects was LA-SRa -2.11 ± 0.61 s(-1) and LA-Strain 45.5 ± 11.4%, and the lowest expected values of these LA analyses (calculated as -1.96 SD from the mean of healthy subjects) were LA-SRa -0.91 s(-1) and LA-Strain 23.1%. Concerning the clinical relevance of these LA myocardial analyses, LA-SRa and LA-Strain detected subtle LA dysfunction in patients with LVDD, even though LA volumetric measurements were normal. In addition, in these patients we found that the functional class (dyspnoea-NYHA classification) was inversely related to both LA-Strain and LA-SRa. CONCLUSION: In the present multicentre study analysing a large cohort of healthy subjects and patients with LVDD, the normal range and the clinical relevance of the myocardial function of the LA using 2DSTE have been determined. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: The aim of this multicentre study was to determine the normal range and the clinical relevance of the myocardial function of the left atrium (LA) analysed by 2D speckle-tracking echocardiography (2DSTE). METHODS AND RESULTS: We analysed 329 healthy adult subjects prospectively included in 10 centres and a validation group of 377 patients with left ventricular diastolic dysfunction (LVDD). LA myocardial function was analysed by LA strain rate peak during LA contraction (LA-SRa) and LA strain peak during LA relaxation (LA-Strain). The range of values of LA myocardial function in healthy subjects was LA-SRa -2.11 ± 0.61 s(-1) and LA-Strain 45.5 ± 11.4%, and the lowest expected values of these LA analyses (calculated as -1.96 SD from the mean of healthy subjects) were LA-SRa -0.91 s(-1) and LA-Strain 23.1%. Concerning the clinical relevance of these LA myocardial analyses, LA-SRa and LA-Strain detected subtle LA dysfunction in patients with LVDD, even though LA volumetric measurements were normal. In addition, in these patients we found that the functional class (dyspnoea-NYHA classification) was inversely related to both LA-Strain and LA-SRa. CONCLUSION: In the present multicentre study analysing a large cohort of healthy subjects and patients with LVDD, the normal range and the clinical relevance of the myocardial function of the LA using 2DSTE have been determined. Published on behalf of the European Society of Cardiology. All rights reserved.
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