Satoru Kishi1, Tiago A Magalhaes1, Richard T George1, Marc Dewey2, Roger J Laham3, Hiroyuki Niinuma4, Lisa Aronson Friedman5, Christopher Cox5, Yutaka Tanami6, Joanne D Schuijf7, Andrea L Vavere1, Kakuya Kitagawa8, Marcus Y Chen9, Cesar H Nomura10, Jeffrey A Brinker1, Frank J Rybicki11, Marcelo F Di Carli11, Armin Arbab-Zadeh1, Joao A C Lima12. 1. Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Blalock 524, 600 N. Wolfe Street, Baltimore, MD 21287, USA. 2. Department of Radiology, Charité Medical School, Humboldt-Universität zu Berline and Freie Universität zu Berlin, Berlin, Germany. 3. Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA. 4. Division of Cardiology, St. Luke's International Hospital, Tokyo, Japan. 5. Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 6. Department of Radiology, Keio University, Tokyo, Japan. 7. Toshiba Medical Systems Europe B.V., Zoetermeer, The Netherlands. 8. Department of Radiology, Mie University Hospital, Tsu, Japan. 9. Advanced Cardiovascular Imaging Group, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. 10. Radiology Sector, Hospital Israelita Albert Einstein, São Paulo, Brazil. 11. Department of Radiology, Brigham and Women's Hospital, Harvard University, Boston, MA, USA. 12. Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Blalock 524, 600 N. Wolfe Street, Baltimore, MD 21287, USA jlima@jhmi.edu.
Abstract
AIMS: The aim of this study was to investigate the association of left ventricular mass (LVM) with coronary atherosclerosis and myocardial infarction (MI). METHODS AND RESULTS: Patients (n = 338) underwent 320 × 0.5 mm detector row coronary computed tomography (CT) angiography, invasive coronary angiography (ICA), and single-photon emission CT (SPECT) myocardial perfusion imaging. Quantitative coronary atheroma volume was obtained from the CT images for the entire coronary tree (19-segment model) with an arterial contour detection algorithm. Normalized total atheroma volume (NormTAV) was analysed to reflect quantitative total atheroma volume. LVM was measured on myocardial CT images and indexed to height to the power of 2.7 (LVMi). Patients with obstructive coronary artery disease (CAD) were defined as those with ≥50% diameter stenosis by quantitative ICA. Abnormal perfusion defect was defined as ≥1 abnormal myocardial segment by SPECT. The association of LVMi with coronary atherosclerosis and myocardial perfusion defect on SPECT at the patient level was determined with uni- and multivariable linear and logistic regression analyses. Obstructive CAD was present in 60.0% of enrolled patients. LVMi was independently associated with abnormal summed rest score [SRS; odds ratio (OR), 1.07; 95% confidence interval (CI), 1.03-1.09] and summed stress score (OR, 1.04; 95% CI, 1.01-1.07). An increase in LVMi was also independently associated with that in NormTAV (coefficient, 10.44; 95% CI, 1.50-19.39) and SRS ≥1 (OR, 1.05; 95% CI, 1.01-1.10), even after adjusting for cardiovascular risk factors in patients without previous MI. CONCLUSIONS: LVM was independently associated with the presence of coronary artery atherosclerosis and MI. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: The aim of this study was to investigate the association of left ventricular mass (LVM) with coronary atherosclerosis and myocardial infarction (MI). METHODS AND RESULTS:Patients (n = 338) underwent 320 × 0.5 mm detector row coronary computed tomography (CT) angiography, invasive coronary angiography (ICA), and single-photon emission CT (SPECT) myocardial perfusion imaging. Quantitative coronary atheroma volume was obtained from the CT images for the entire coronary tree (19-segment model) with an arterial contour detection algorithm. Normalized total atheroma volume (NormTAV) was analysed to reflect quantitative total atheroma volume. LVM was measured on myocardial CT images and indexed to height to the power of 2.7 (LVMi). Patients with obstructive coronary artery disease (CAD) were defined as those with ≥50% diameter stenosis by quantitative ICA. Abnormal perfusion defect was defined as ≥1 abnormal myocardial segment by SPECT. The association of LVMi with coronary atherosclerosis and myocardial perfusion defect on SPECT at the patient level was determined with uni- and multivariable linear and logistic regression analyses. Obstructive CAD was present in 60.0% of enrolled patients. LVMi was independently associated with abnormal summed rest score [SRS; odds ratio (OR), 1.07; 95% confidence interval (CI), 1.03-1.09] and summed stress score (OR, 1.04; 95% CI, 1.01-1.07). An increase in LVMi was also independently associated with that in NormTAV (coefficient, 10.44; 95% CI, 1.50-19.39) and SRS ≥1 (OR, 1.05; 95% CI, 1.01-1.10), even after adjusting for cardiovascular risk factors in patients without previous MI. CONCLUSIONS: LVM was independently associated with the presence of coronary artery atherosclerosis and MI. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Michiel A de Graaf; Alexander Broersen; Pieter H Kitslaar; Cornelis J Roos; Jouke Dijkstra; Boudewijn P F Lelieveldt; J Wouter Jukema; Martin J Schalij; Victoria Delgado; Jeroen J Bax; Johan H C Reiber; Arthur J Scholte Journal: Int J Cardiovasc Imaging Date: 2013-02-16 Impact factor: 2.357
Authors: Carlos E Rochitte; Richard T George; Marcus Y Chen; Armin Arbab-Zadeh; Marc Dewey; Julie M Miller; Hiroyuki Niinuma; Kunihiro Yoshioka; Kakuya Kitagawa; Shiro Nakamori; Roger Laham; Andrea L Vavere; Rodrigo J Cerci; Vishal C Mehra; Cesar Nomura; Klaus F Kofoed; Masahiro Jinzaki; Sachio Kuribayashi; Albert de Roos; Michael Laule; Swee Yaw Tan; John Hoe; Narinder Paul; Frank J Rybicki; Jeffery A Brinker; Andrew E Arai; Christopher Cox; Melvin E Clouse; Marcelo F Di Carli; Joao A C Lima Journal: Eur Heart J Date: 2013-11-19 Impact factor: 29.983
Authors: Mabruka A Alfaidi; Janet Chamberlain; Alexander Rothman; David Crossman; Maria-Cruz Villa-Uriol; Patrick Hadoke; Junxi Wu; Torsten Schenkel; Paul C Evans; Sheila E Francis Journal: J Am Heart Assoc Date: 2018-06-30 Impact factor: 5.501