OBJECTIVE: To intra-individually assess the association of inflammation severity and cartilage composition measured by RAMRIS synovitis sub-score and delayed gadolinium-enhanced magnetic resonance imaging of the cartilage (dGEMRIC) of metacarpophalangeal (MCP) joints in patients with rheumatoid arthritis (RA). METHODS: Forty-three patients with RA according to ACR/EULAR classification criteria (age 52.9 ± 14.5 years, range, 18-77 years) were included in this study. All study participants received 3-T MRI scans of the metacarpophalangeal joints of the second and third finger (MCP 2 and 3). The severity of synovitis was scored according to the RAMRIS synovitis sub-score by two readers in consensus. In the cases with identical synovitis sub-scores, two radiologists decided in consensus on the joint with more severe synovitis. Cartilage composition was assessed with dGEMRIC. To test the association of inflammation severity and cartilage damage and in order to eliminate inter-patient confounders, each patient's MCP 2 and 3 were dichotomized into the joint with more severe synovitis versus the joint with less severe synovitis for a paired Wilcoxon test of dGEMRIC value. RESULTS: There was a significant difference of dGEMRIC value (median of difference: 47.12, CI [16.6; 62.76]) between the dichotomized MCPs (p = 0.0001). There was a significant correlation between dGEMRIC value and RAMRIS synovitis grading of the joint with more severe synovitis (r = 0.5; p < 0.05) and the joint with less severe synovitis (r = 0.33; p < 0.05). CONCLUSIONS: Our data concur with the concept that synovitis severity is associated with cartilage damage. The local inflammatory status on a joint level correlated significantly with the extent of cartilage degradation in biochemical MRI.
OBJECTIVE: To intra-individually assess the association of inflammation severity and cartilage composition measured by RAMRIS synovitis sub-score and delayed gadolinium-enhanced magnetic resonance imaging of the cartilage (dGEMRIC) of metacarpophalangeal (MCP) joints in patients with rheumatoid arthritis (RA). METHODS: Forty-three patients with RA according to ACR/EULAR classification criteria (age 52.9 ± 14.5 years, range, 18-77 years) were included in this study. All study participants received 3-T MRI scans of the metacarpophalangeal joints of the second and third finger (MCP 2 and 3). The severity of synovitis was scored according to the RAMRIS synovitis sub-score by two readers in consensus. In the cases with identical synovitis sub-scores, two radiologists decided in consensus on the joint with more severe synovitis. Cartilage composition was assessed with dGEMRIC. To test the association of inflammation severity and cartilage damage and in order to eliminate inter-patient confounders, each patient's MCP 2 and 3 were dichotomized into the joint with more severe synovitis versus the joint with less severe synovitis for a paired Wilcoxon test of dGEMRIC value. RESULTS: There was a significant difference of dGEMRIC value (median of difference: 47.12, CI [16.6; 62.76]) between the dichotomized MCPs (p = 0.0001). There was a significant correlation between dGEMRIC value and RAMRIS synovitis grading of the joint with more severe synovitis (r = 0.5; p < 0.05) and the joint with less severe synovitis (r = 0.33; p < 0.05). CONCLUSIONS: Our data concur with the concept that synovitis severity is associated with cartilage damage. The local inflammatory status on a joint level correlated significantly with the extent of cartilage degradation in biochemical MRI.
Authors: Daniel Aletaha; Tuhina Neogi; Alan J Silman; Julia Funovits; David T Felson; Clifton O Bingham; Neal S Birnbaum; Gerd R Burmester; Vivian P Bykerk; Marc D Cohen; Bernard Combe; Karen H Costenbader; Maxime Dougados; Paul Emery; Gianfranco Ferraccioli; Johanna M W Hazes; Kathryn Hobbs; Tom W J Huizinga; Arthur Kavanaugh; Jonathan Kay; Tore K Kvien; Timothy Laing; Philip Mease; Henri A Ménard; Larry W Moreland; Raymond L Naden; Theodore Pincus; Josef S Smolen; Ewa Stanislawska-Biernat; Deborah Symmons; Paul P Tak; Katherine S Upchurch; Jirí Vencovský; Frederick Wolfe; Gillian Hawker Journal: Arthritis Rheum Date: 2010-09
Authors: Hans Liebl; Gabby Joseph; Michael C Nevitt; Nathan Singh; Ursula Heilmeier; Karupppasamy Subburaj; Pia M Jungmann; Charles E McCulloch; John A Lynch; Nancy E Lane; Thomas M Link Journal: Ann Rheum Dis Date: 2014-03-10 Impact factor: 19.103
Authors: Michel D Crema; Frank W Roemer; Monica D Marra; Deborah Burstein; Garry E Gold; Felix Eckstein; Thomas Baum; Timothy J Mosher; John A Carrino; Ali Guermazi Journal: Radiographics Date: 2011 Jan-Feb Impact factor: 5.333
Authors: Carl Johan Tiderius; Joakim Sandin; Jonas Svensson; Leif E Dahlberg; Lennart Jacobsson Journal: Acta Radiol Date: 2010-11 Impact factor: 1.990
Authors: M L Hetland; B Ejbjerg; K Hørslev-Petersen; S Jacobsen; A Vestergaard; A G Jurik; K Stengaard-Pedersen; P Junker; T Lottenburger; I Hansen; L S Andersen; U Tarp; H Skjødt; J K Pedersen; O Majgaard; A J Svendsen; T Ellingsen; H Lindegaard; A F Christensen; J Vallø; T Torfing; E Narvestad; H S Thomsen; M Ostergaard Journal: Ann Rheum Dis Date: 2008-04-03 Impact factor: 19.103
Authors: Paco M J Welsing; Robert B M Landewé; Piet L C M van Riel; Maarten Boers; Anke M van Gestel; Sjef van der Linden; Hilde L Swinkels; Désirée M F M van der Heijde Journal: Arthritis Rheum Date: 2004-07
Authors: Philip Conaghan; Marissa Lassere; Mikkel Østergaard; Charles Peterfy; Fiona McQueen; Philip O'Connor; Paul Bird; Bo Ejbjerg; Mette Klarlund; Ron Shnier; Harry Genant; Paul Emery; John Edmonds Journal: J Rheumatol Date: 2003-06 Impact factor: 4.666
Authors: Daniel B Abrar; Christoph Schleich; Sven Nebelung; Miriam Frenken; Tim Ullrich; Karl Ludger Radke; Gerald Antoch; Stefan Vordenbäumen; Ralph Brinks; Matthias Schneider; Benedikt Ostendorf; Philipp Sewerin Journal: Arthritis Res Ther Date: 2020-05-29 Impact factor: 5.156
Authors: Anouk M Barendregt; Valentina Mazzoli; J Merlijn van den Berg; Taco W Kuijpers; Mario Maas; Aart J Nederveen; Robert Hemke Journal: Pediatr Radiol Date: 2019-11-09