Literature DB >> 25367414

Effect of amphiphilic PCL-PEG nano-micelles on HepG2 cell migration.

Yang Shen1, Mengtian Leng, Hongchi Yu, Qin Zhang, Xianglin Luo, Hans Gregersen, Guixue Wang, Xiaoheng Liu.   

Abstract

Uptake of nanoparticles (NPs) affects cell migration but the mechanism remains poorly understood. In this study, the amphiphilic block PCL-PEG nano-micelles with well-controlled hydrophilic/hydrophobic chains were used to investigate the effect of internalized nano-micelles on cancer cell migration. Our results indicated that the nano-micelles with medium PCL and PEG chains increased expression of Rho GTPases and impeded focal adhesion components. This could enhance Hep G2 cell motility. The nano-micelles with large PCL and PEG chains showed lower Rho GTPase levels and higher FA components. This is consistent with slower cell migration. Understanding the mechanism of NPs regulating cell behaviors may help the design of efficient drug delivery systems based on polymer micelles.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  PCL-PEG; Rho GTPases; amphiphiles; biodegradable; cell migration

Mesh：

Substances：

Year:  2014        PMID： 25367414     DOI： 10.1002/mabi.201400376

Source DB:  PubMed          Journal:  Macromol Biosci        ISSN： 1616-5187            Impact factor:   4.979


  8 in total

1.  Targeting Cancer by Using Nanoparticles to Modulate RHO GTPase Signaling.

Authors:  Paulo Matos; Joana F S Pereira; Peter Jordan
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 2.622

2.  Toxicity evaluations of nanoclays and thermally degraded byproducts through spectroscopical and microscopical approaches.

Authors:  Alixandra Wagner; Reem Eldawud; Andrew White; Sushant Agarwal; Todd A Stueckle; Konstantinos A Sierros; Yon Rojanasakul; Rakesh K Gupta; Cerasela Zoica Dinu
Journal:  Biochim Biophys Acta Gen Subj       Date:  2016-09-07       Impact factor: 3.770

3.  Potential antitumor activity of digitoxin and user-designed analog administered to human lung cancer cells.

Authors:  Reem Eldawud; Alixandra Wagner; Chenbo Dong; Neha Gupta; Yon Rojanasakul; George O'Doherty; Todd A Stueckle; Cerasela Zoica Dinu
Journal:  Biochim Biophys Acta Gen Subj       Date:  2020-07-15       Impact factor: 3.770

4.  PEG-b-PCL polymeric nano-micelle inhibits vascular angiogenesis by activating p53-dependent apoptosis in zebrafish.

Authors:  Tian Zhou; Qinglei Dong; Yang Shen; Wei Wu; Haide Wu; Xianglin Luo; Xiaoling Liao; Guixue Wang
Journal:  Int J Nanomedicine       Date:  2016-12-05

5.  Nanoparticle-mediated dual delivery of resveratrol and DAP5 ameliorates kidney ischemia/reperfusion injury by inhibiting cell apoptosis and inflammation.

Authors:  Yong Xu; Bo Zhang; Da Xie; Yu Hu; Hai-Lun Li; Li-Li Zhong; Hong-Wu Wang; Wei Jiang; Zun-Ping Ke; Dong-Hui Zheng
Journal:  Oncotarget       Date:  2017-06-13

Review 6.  Small GTPases: Structure, biological function and its interaction with nanoparticles.

Authors:  Siyang Song; Wenshu Cong; Shurong Zhou; Yujie Shi; Wenbing Dai; Hua Zhang; Xueqing Wang; Bing He; Qiang Zhang
Journal:  Asian J Pharm Sci       Date:  2018-07-31       Impact factor: 6.598

7.  Antitumor Activity of Thermosensitive Hydrogels Packaging Gambogic Acid Nanoparticles and Tumor-Penetrating Peptide iRGD Against Gastric Cancer.

Authors:  Dinghu Zhang; Yanhong Chu; Hanqing Qian; Lingyu Qian; Jie Shao; Qiuping Xu; Lixia Yu; Rutian Li; Quanan Zhang; Fenglei Wu; Baorui Liu; Qin Liu
Journal:  Int J Nanomedicine       Date:  2020-01-31

Review 8.  Biological responses to nanomaterials: understanding nano-bio effects on cell behaviors.

Authors:  Xi-Qiu Liu; Rui-Zhi Tang
Journal:  Drug Deliv       Date:  2017-12       Impact factor: 6.419
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.