Literature DB >> 2536622

myo-inositol 1,4,5-trisphosphorothioate is a potent competitive inhibitor of human erythrocyte 5-phosphatase.

A M Cooke1, S R Nahorski, B V Potter.   

Abstract

The effect of the myo-inositol 1,4,5-trisphosphate (IP3) analogue, myo-inositol 1,4,5-trisphosphorothioate (IPS3) on the dephosphorylation of D-5-[32P]IP3 by the 5-phosphatase from human erythrocyte membranes has been investigated. DL-IPS3 was found to act as a competitive inhibitor with a Ki of 6 microM, making it the most potent inhibitor currently available for this enzyme. L-IP3 inhibited the enzyme with a Ki of 124 microM and was more potent than D-2,3-diphosphoglycerate (Ki 978 microM).

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Year:  1989        PMID： 2536622     DOI： 10.1016/0014-5793(89)80504-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Computer simulation of a cytosolic calcium oscillator.

Authors:  S Swillens; D Mercan
Journal:  Biochem J       Date:  1990-11-01       Impact factor: 3.857

2.  Relationships between the degree of cross-linking of surface immunoglobulin and the associated inositol 1,4,5-trisphosphate and Ca2+ signals in human B cells.

Authors:  F M McConnell; S B Shears; P J Lane; M S Scheibel; E A Clark
Journal:  Biochem J       Date:  1992-06-01       Impact factor: 3.857

3.  Multiple isomers of inositol pentakisphosphate in Epstein-Barr-virus- transformed (T5-1) B-lymphocytes. Identification of inositol 1,3,4,5,6-pentakisphosphate, D-inositol 1,2,4,5,6-pentakisphosphate and L-inositol 1,2,4,5,6-pentakisphosphate.

Authors:  F M McConnell; L R Stephens; S B Shears
Journal:  Biochem J       Date:  1991-12-01       Impact factor: 3.857

4.  Inositol 1,4,5-trisphosphorothioate, a stable analogue of inositol trisphosphate which mobilizes intracellular calcium.

Authors:  C W Taylor; M J Berridge; A M Cooke; B V Potter
Journal:  Biochem J       Date:  1989-05-01       Impact factor: 3.857

5.  Inositol 1,3,4,5-tetrakisphosphate is essential for sustained activation of the Ca2+-dependent K+ current in single internally perfused mouse lacrimal acinar cells.

Authors:  L Changya; D V Gallacher; R F Irvine; B V Potter; O H Petersen
Journal:  J Membr Biol       Date:  1989-07       Impact factor: 1.843

6.  Facilitation of the responses to injections of inositol 1,4,5-trisphosphate analogs in Limulus ventral photoreceptors.

Authors:  I Levitan; R Payne; B V Potter; P Hillman
Journal:  Biophys J       Date:  1994-09       Impact factor: 4.033

7.  Inhibition of inositol 1,4,5-trisphosphate 5-phosphatase by micromolar concentrations of disulfiram and its analogues.

Authors:  C J Fowler; G Brännström; P C Ahlgren; L Florvall; K E Akerman
Journal:  Biochem J       Date:  1993-02-01       Impact factor: 3.857

8.  A correlation of the outcome of clinical in vitro fertilization with the inositol content and embryotrophic properties of human serum.

Authors:  T T Chiu; P P Tam
Journal:  J Assist Reprod Genet       Date:  1992-12       Impact factor: 3.412

9.  Bovine testis and human erythrocytes contain different subtypes of membrane-associated Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphomonoesterases.

Authors:  M Hodgkin; A Craxton; J B Parry; P J Hughes; B V Potter; R H Michell; C J Kirk
Journal:  Biochem J       Date:  1994-02-01       Impact factor: 3.857

10.  Kinetics of activation and inactivation of swelling-stimulated K+/Cl- transport. The volume-sensitive parameter is the rate constant for inactivation.

Authors:  M L Jennings; N al-Rohil
Journal:  J Gen Physiol       Date:  1990-06       Impact factor: 4.086
  10 in total

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