Farhad Zamani1, Masoudreza Sohrabi2, Abbas Alipour3, Nima Motamed2, Fateme Sima Saeedian2, Reza Pirzad4, Khadijeh Abedi4, Mansoreh Maadi2, Hossein Ajdarkosh2, Gholamreza Hemmasi2, Mahmood Khonsari2. 1. Gastrointestinal and Liver Disease Research Center (GILDRC), Iran University of Medical Science, Firoozgar Hospital, Tehran, Iran. Zamani.f@iums.ac.ir. 2. Gastrointestinal and Liver Disease Research Center (GILDRC), Iran University of Medical Science, Firoozgar Hospital, Tehran, Iran. 3. Community Medicine Department, Medical School, Mazandaran University of Medical Sciences, Mazandaran, Iran. 4. 17 shahrivar Hospital, Amol, Mazandaran University of Medical Sciences, Mazandaran, Iran.
Abstract
BACKGROUND: Cholelithiasis is one of the most prevalent gastrointestinal disorders requiring hospitalization. While different factors influence gallstone formation in patients, these factors are not the same in different societies or in different geographical locations. AIM: To evaluate the epidemiology and risk factors associated with gallstone formation in a large population group, the present survey was conducted in northern Iran. METHODS: In 6143 asymptomatic subjects, the incidence of gallstone formation as well as risk factors were evaluated through a structured questionnaire, physical examination and ultrasonography study. Sample selection was based on stratified cluster systemic randomization. RESULTS: Of these enrolled subjects 3507 (57.1%) were male and 2636 (42.9%) were female with a mean age of 42.71 ± 17.1 years. The prevalence of gallstones was 0.80%. On multivariate analysis, the risk of gallstone disease is correlated to rural locale, diastolic hypertension, age, and TG levels. However, systolic hypertension, glucose serum levels and obesity were also significantly associated with the presence of gallstones. CONCLUSION: The present study proposes that the rate of gallstone disease in northern Iran is lower than previous studies have reported, and that most of the risk factors can be prevented by changes in lifestyle and diet.
BACKGROUND:Cholelithiasis is one of the most prevalent gastrointestinal disorders requiring hospitalization. While different factors influence gallstone formation in patients, these factors are not the same in different societies or in different geographical locations. AIM: To evaluate the epidemiology and risk factors associated with gallstone formation in a large population group, the present survey was conducted in northern Iran. METHODS: In 6143 asymptomatic subjects, the incidence of gallstone formation as well as risk factors were evaluated through a structured questionnaire, physical examination and ultrasonography study. Sample selection was based on stratified cluster systemic randomization. RESULTS: Of these enrolled subjects 3507 (57.1%) were male and 2636 (42.9%) were female with a mean age of 42.71 ± 17.1 years. The prevalence of gallstones was 0.80%. On multivariate analysis, the risk of gallstone disease is correlated to rural locale, diastolic hypertension, age, and TG levels. However, systolic hypertension, glucose serum levels and obesity were also significantly associated with the presence of gallstones. CONCLUSION: The present study proposes that the rate of gallstone disease in northern Iran is lower than previous studies have reported, and that most of the risk factors can be prevented by changes in lifestyle and diet.
Authors: Nima Motamed; Alireza Mardanshahi; Benyamin Mohseni Saravi; Hasan Siamian; Mansooreh Maadi; Farhad Zamani Journal: Mater Sociomed Date: 2015-06-08
Authors: Seyed Vahid Hosseini; Abbass Ayoub; Abbas Rezaianzadeh; Ali Mohammad Bananzadeh; Leila Ghahramani; Salar Rahimikazerooni; Hajar Khazraei Journal: Adv Biomed Res Date: 2016-08-30