Renal excretion of prostanoids and cyclic AMP in chronic partial ureteral obstruction of the rabbit.

The renal excretion of prostaglandins E2 and 6-keto-F1 alpha, thromboxane B2 and cyclic adenosine 3', 5'-monophosphate was measured in a solitary kidney model of chronic ureteral obstruction in rabbits. The presence of obstruction was confirmed by intravenous pyelography. Growth rate of the animals and furosemide-stimulated diethylenetriaminepentaacetic acid renography were used to grade the obstruction. As correlated to urinary creatinine concentration the excretion of 6-keto-PGF1 alpha dominated in nephrectomized, unobstructed control animals. With the degree of ureteral obstruction becoming more severe, the output of PGE2 increased, while that of 6-keto-PGF1 alpha and TxB2 decreased. As a result the ratios PGE2/6-keto-PGF1 alpha and PGE2/TxB2 were three times as high in severely obstructed rabbits as in control animals. The renal output of cyclic AMP was unaffected by chronic obstruction. We conclude that the renal metabolism of prostanoids is affected in a unique way in chronic partial obstruction of the ureter.