Literature DB >> 2536394

Motor dominant neuropathy and IgM paraproteinemia: the IgM M-protein binds to specific gangliosides.

S Kusunoki1, T Shimizu, K Matsumura, K Maemura, T Mannen.   

Abstract

In a case of motor-dominant neuropathy and IgM paraproteinemia, the binding specificity of the serum IgM M-protein was characterized by enzyme-linked immunosorbent assay (ELISA). The serum IgM M-protein bound preferentially to ganglioside GM1 with slight cross-reactivity to both GM2 and GD1b. The binding specificity of the antibody and clinicopathological features are discussed.

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Year:  1989        PMID： 2536394     DOI： 10.1016/0165-5728(89)90173-2

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  4 in total

Review 1.  Monoclonal IgM autoantibody reactivity in M-IgM peripheral neuropathy.

Authors:  C Caudie
Journal:  Clin Rev Allergy Immunol       Date:  2000-08       Impact factor: 8.667

2.  Human monoclonal IgM with autoantibody activity against two gangliosides (GM1 and GD1b) in a patient with motor neuron syndrome.

Authors:  M O Jauberteau; N Gualde; J L Preud'Homme; M Rigaud; R Gil; J M Vallat; N Baumann
Journal:  Clin Exp Immunol       Date:  1990-05       Impact factor: 4.330

3.  Experimental autoimmune neuropathy with anti-GM1 antibodies and immunoglobulin deposits at the nodes of Ranvier.

Authors:  F P Thomas; W Trojaborg; C Nagy; M Santoro; S A Sadiq; N Latov; A P Hays
Journal:  Acta Neuropathol       Date:  1991       Impact factor: 17.088

Review 4.  Gangliosides. Their role in clinical neurology.

Authors:  E Nobile-Orazio; M Carpo; G Scarlato
Journal:  Drugs       Date:  1994-04       Impact factor: 9.546
  4 in total

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