| Literature DB >> 25361551 |
Gustavo Tadeu Volpato1, Débora Cristina Damasceno2, Yuri Karen Sinzato2, Viviane Maria Ribeiro2, Marilza Vieira Cunha Rudge2, Iracema Mattos Paranhos Calderon2.
Abstract
The potential benefits and risks of physical exercise on fetal development during pregnancy remain unclear. The aim was to analyze maternal oxidative stress status and the placental morphometry to relate to intrauterine growth restriction (IUGR) from diabetic female rats submitted to swimming program after embryonic implantation. Pregnant Wistar rats were distributed into 4 groups (11 animals/group): control-nondiabetic sedentary rats, control exercised-nondiabetic exercised rats, diabetic-diabetic sedentary rats, and diabetic exercised-diabetic exercised rats. A swimming program was used as an exercise model. At the end of pregnancy, the maternal oxidative stress status, placental morphology, and fetal weight were analyzed. The swimming program was not efficient to reduce the hyperglycemia-induced oxidative stress. This fact impaired placental development, resulting in altered blood flow and energy reserves, which contributed to a deficient exchange of nutrients and oxygen for the fetal development, leading to IUGR.Entities:
Keywords: diabetes; oxidative stress; physical exercise; placenta; pregnancy
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Year: 2014 PMID： 25361551 PMCID： PMC4519768 DOI： 10.1177/1933719114556485
Source DB: PubMed Journal: Reprod Sci ISSN： 1933-7191 Impact factor: 3.060