Literature DB >> 2536123

Phosphorylation at serine 89 induces a shift in gel mobility but has little effect on the function of adenovirus type 5 E1A proteins.

D J Dumont1, M L Tremblay, P E Branton.   

Abstract

Phosphorylation at serine 89 was shown to be the major cause of the shift in gel migration of the 289R and 243R early region 1A (E1A) proteins of human adenovirus type 5. However, conversion of Ser-89 to alanine by site-directed mutagenesis did not abolish E1A transactivating or transforming activities, suggesting that phosphorylation at this site is not necessary for these E1A functions.

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Year:  1989        PMID： 2536123      PMCID： PMC247781     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  31 in total

1.  A new technique for the assay of infectivity of human adenovirus 5 DNA.

Authors:  F L Graham; A J van der Eb
Journal:  Virology       Date:  1973-04       Impact factor: 3.616

2.  Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses.

Authors:  M Perricaudet; G Akusjärvi; A Virtanen; U Pettersson
Journal:  Nature       Date:  1979-10-25       Impact factor: 49.962

3.  Transformation properties of type 5 adenovirus mutants that differentially express the E1A gene products.

Authors:  K P Haley; J Overhauser; L E Babiss; H S Ginsberg; N C Jones
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

4.  Characterization of human adenovirus type 5 early region 1A polypeptides using antitumor sera and an antiserum specific for the carboxy terminus.

Authors:  D T Rowe; S P Yee; J Otis; F L Graham; P E Branton
Journal:  Virology       Date:  1983-06       Impact factor: 3.616

5.  Adenovirus type 2 early proteins: assignment of the early region 1A proteins synthesized in vivo and in vitro to specific mRNAs.

Authors:  J E Smart; J B Lewis; M B Mathews; M L Harter; C W Anderson
Journal:  Virology       Date:  1981-07-30       Impact factor: 3.616

6.  Early region 1B of adenovirus 2 encodes two coterminal proteins of 495 and 155 amino acid residues.

Authors:  C W Anderson; R C Schmitt; J E Smart; J B Lewis
Journal:  J Virol       Date:  1984-05       Impact factor: 5.103

7.  Adenovirus type 2 early proteins synthesized in vitro and in vivo: identification in infected cells of the 38,000- to 50,000- molecular-weight protein encoded by the left end of the adenovirus type 2 genome.

Authors:  M L Harter; J B Lewis
Journal:  J Virol       Date:  1978-06       Impact factor: 5.103

8.  A first exon-encoded domain of E1A sufficient for posttranslational modification, nuclear-localization, and induction of adenovirus E3 promoter expression in Xenopus oocytes.

Authors:  J D Richter; P Young; N C Jones; B Krippl; M Rosenberg; B Ferguson
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

9.  Identification of human adenovirus early region 1 products by using antisera against synthetic peptides corresponding to the predicted carboxy termini.

Authors:  S P Yee; D T Rowe; M L Tremblay; M McDermott; P E Branton
Journal:  J Virol       Date:  1983-06       Impact factor: 5.103

10.  Tn5 mutagenesis of the transforming genes of human adenovirus type 5.

Authors:  R D McKinnon; S Bacchetti; F L Graham
Journal:  Gene       Date:  1982 Jul-Aug       Impact factor: 3.688
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  13 in total

1.  Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1.

Authors:  U Müller; T Kleinberger; T Shenk
Journal:  J Virol       Date:  1992-10       Impact factor: 5.103

Review 2.  Expression and interactions of human adenovirus oncoproteins.

Authors:  P A Boulanger; G E Blair
Journal:  Biochem J       Date:  1991-04-15       Impact factor: 3.857

3.  Phosphorylation within the transactivation domain of adenovirus E1A protein by mitogen-activated protein kinase regulates expression of early region 4.

Authors:  S G Whalen; R C Marcellus; A Whalen; N G Ahn; R P Ricciardi; P E Branton
Journal:  J Virol       Date:  1997-05       Impact factor: 5.103

4.  The human cytomegalovirus 86-kilodalton immediate-early 2 protein: synthesis as a precursor polypeptide and interaction with a 75-kilodalton protein of probable viral origin.

Authors:  L A Samaniego; M J Tevethia; D J Spector
Journal:  J Virol       Date:  1994-02       Impact factor: 5.103

5.  Functional importance of complex formation between the retinoblastoma tumor suppressor family and adenovirus E1A proteins as determined by mutational analysis of E1A conserved region 2.

Authors:  H B Corbeil; P E Branton
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103

6.  Importance of the Ser-132 phosphorylation site in cell transformation and apoptosis induced by the adenovirus type 5 E1A protein.

Authors:  S G Whalen; R C Marcellus; D Barbeau; P E Branton
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

7.  Mutations that affect phosphorylation of the adenovirus DNA-binding protein alter its ability to enhance its own synthesis.

Authors:  N Morin; C Delsert; D F Klessig
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

8.  Regulation of p53-dependent apoptosis, transcriptional repression, and cell transformation by phosphorylation of the 55-kilodalton E1B protein of human adenovirus type 5.

Authors:  J G Teodoro; P E Branton
Journal:  J Virol       Date:  1997-05       Impact factor: 5.103

9.  Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis.

Authors:  R C Marcellus; J G Teodoro; T Wu; D E Brough; G Ketner; G C Shore; P E Branton
Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

10.  Phosphorylation at the carboxy terminus of the 55-kilodalton adenovirus type 5 E1B protein regulates transforming activity.

Authors:  J G Teodoro; T Halliday; S G Whalen; D Takayesu; F L Graham; P E Branton
Journal:  J Virol       Date:  1994-02       Impact factor: 5.103
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