Literature DB >> 25360217

Maytansine-loaded star-shaped folate-core PLA-TPGS nanoparticles enhancing anticancer activity.

Xiaolong Tang1, Hong Dai2, Yongxiang Zhu1, Ye Tian3, Rongbo Zhang3, Rengbiao Mei3, Deqiang Li4.   

Abstract

The efficient delivery of therapeutic molecule agents into target cells of interest is a critical challenge to broad application of non-viral vector systems. In this research, maytansine-loaded star-shaped folate-core polylactide-D-α-tocopheryl polyethylene glycol 1000 succinate (FA-PLA-TPGS) block copolymer was applied to be a vector of maytansine for folate receptor positive (FR(+)) breast cancer therapy. The uptake of maytansine nanoparticles by SKBR3 cells were observed by fluorescence microscopy and confocal laser scanning microscopy. The cell viability of maytansine-NPs in SKBR3 cells was assessed according to the changed level of intracellular microtubules and apoptosis-associated proteins. The cytotoxicity of the SKBR3 cells was significantly increased by maytansine-NPs when compared with control groups. In conclusion, the maytansine-NPs offer a considerable potential formulation for FR-expressing tumor targeting biotherapy.

Entities:  

Keywords:  Maytansine; chemotherapy; folate; nanomedicine; targeted delivery

Year:  2014        PMID： 25360217      PMCID： PMC4212927     

Source DB:  PubMed          Journal:  Am J Transl Res            Impact factor:   4.060


  30 in total

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Authors:  Erina Vlashi; Lindsay E Kelderhouse; Jennifer E Sturgis; Philip S Low
Journal:  ACS Nano       Date:  2013-09-17       Impact factor: 15.881

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Authors:  Ilyes Benchaala; Manoj K Mishra; Susan M Wykes; Mirabela Hali; Rangaramanujam M Kannan; Judith A Whittum-Hudson
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4.  The reduction of anti-cancer drug antagonism by the spatial protection of drugs with PLA-TPGS nanoparticles.

Authors:  Guang-Rong Tan; Si-Shen Feng; David T Leong
Journal:  Biomaterials       Date:  2014-01-15       Impact factor: 12.479

5.  In vitro and in vivo investigation on PLA-TPGS nanoparticles for controlled and sustained small molecule chemotherapy.

Authors:  Zhiping Zhang; Sie Huey Lee; Chee Wee Gan; Si-Shen Feng
Journal:  Pharm Res       Date:  2008-05-29       Impact factor: 4.200

6.  Cytotoxic activity of maytanprine isolated from Maytenus diversifolia in human leukemia K562 cells.

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Journal:  Biol Pharm Bull       Date:  2004-08       Impact factor: 2.233

Review 7.  Antibody-drug conjugates for the treatment of B-cell non-Hodgkin's lymphoma and leukemia.

Authors:  Yu-Waye Chu; Andrew Polson
Journal:  Future Oncol       Date:  2013-03       Impact factor: 3.404

8.  Rapid and soft formulation of folate-functionalized nanoparticles for the targeted delivery of tripentone in ovarian carcinoma.

Authors:  J Tomasina; L Poulain; E Abeilard; F Giffard; E Brotin; L Carduner; F Carreiras; P Gauduchon; S Rault; A Malzert-Fréon
Journal:  Int J Pharm       Date:  2013-09-29       Impact factor: 5.875

9.  Phosphatidylserine-targeted molecular imaging of tumor vasculature by magnetic resonance imaging.

Authors:  Heling Zhou; Jason H Stafford; Rami R Hallac; Liang Zhang; Gang Huang; Ralph P Mason; Jinming Gao; Philip E Thorpe; Dawen Zhao
Journal:  J Biomed Nanotechnol       Date:  2014-05       Impact factor: 4.099

10.  Development of drug delivery systems based on layered hydroxides for nanomedicine.

Authors:  Farahnaz Barahuie; Mohd Zobir Hussein; Sharida Fakurazi; Zulkarnain Zainal
Journal:  Int J Mol Sci       Date:  2014-05-05       Impact factor: 5.923
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  3 in total

1.  Essential oil from Siegesbeckia pubescens induces apoptosis through the mitochondrial pathway in human HepG2 cells.

Authors:  Dan Lv; Kai-Wen Guo; Chan Xu; Mi Huang; Si-Jian Zheng; Xin-Hua Ma; Li-Hong Pan; Qiang Wang; Xin-Zhou Yang
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2017-02-22

2.  The Yunnan national medicine Maytenus compound inhibits the proliferation of hepatocellular carcinoma (HCC) by suppressing the activation of the EGFR-PI3K-AKT signaling pathway.

Authors:  Wen-Tao Zhao; Liu-Xin Han; Lin Liu; Bao-Zhen Zeng; Yi Zhang; Liu-Fang Zhao; Hong-Yan Hu; Jia-Wei Xia; Yi-Ze Li; Xu-Dong Xiang; Xiao-Lin Lin; Di Lu; Gao-Feng Li
Journal:  J Cancer       Date:  2021-04-07       Impact factor: 4.207

3.  Anti-transferrin receptor-modified amphotericin B-loaded PLA-PEG nanoparticles cure Candidal meningitis and reduce drug toxicity.

Authors:  Xiaolong Tang; Yong Liang; Yongqiang Zhu; Chunmei Xie; Aixia Yao; Li Chen; Qinglin Jiang; Tingting Liu; Xiaoyu Wang; Yunyun Qian; Jia Wei; Wenxuan Ni; Jingjing Dai; Zhenyou Jiang; Wei Hou
Journal:  Int J Nanomedicine       Date:  2015-10-05
  3 in total

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