| Literature DB >> 2535996 |
P J Chen1, D S Chen, M Y Lai, M H Chang, G T Huang, P M Yang, J C Sheu, S C Lee, H C Hsu, J L Sung.
Abstract
Recurrence of hepatocellular carcinoma after treatment is frequent. To study the clonal origin of the recurrent tumors, we examined five pairs of hepatocellular carcinomas resected from individual hepatitis B surface antigen carriers. Using integrated hepatitis B virus DNA as a marker, tumor clonality was determined by Southern blot analysis. In 2 cases the second tumor contained the same integrated viral DNA as the first one. In the other 3 cases, the clonality of the second cancer differed. We conclude that recurrent hepatocellular carcinomas originate from the first tumor in some cases but represent de novo neoplasms in others.Entities:
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Year: 1989 PMID： 2535996 DOI： 10.1016/0016-5085(89)91581-3
Source DB: PubMed Journal: Gastroenterology ISSN： 0016-5085 Impact factor: 22.682