Nobuyuki Murakoshi1, DongZhu Xu2, Toshimi Sairenchi3, Miyako Igarashi2, Fujiko Irie4, Takuji Tomizawa5, Hiroshi Tada6, Yukio Sekiguchi6, Kazumasa Yamagishi7, Hiroyasu Iso8, Iwao Yamaguchi5, Hitoshi Ota9, Kazutaka Aonuma6. 1. Cardiovascular Division, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan n.murakoshi@md.tsukuba.ac.jp. 2. Cardiovascular Division, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan. 3. Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan Department of Public Health, Dokkyo Medical University, Mibu, Japan. 4. Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan Department of Health and Welfare, Ibaraki Prefectural Office, Mito, Japan. 5. Ibaraki Health Service Association, Mito, Japan. 6. Cardiovascular Division, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan. 7. Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan Department of Public Health Medicine, University of Tsukuba, Tsukuba, Japan. 8. Department of Social and Environmental Medicine, Osaka University, Osaka, Japan. 9. Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan.
Abstract
AIMS: The long-term prognosis of subjects with supraventricular premature complexes (SVPCs) remains unclear in the general population. The aim of this study was to examine the prognostic significance of SVPCs in community-based health checkups. METHODS AND RESULTS: We assessed 63 197 individuals (mean age, 58.8 ± 9.9 years; 67.6% women) who participated in annual community-based health checkups in 1993 and were followed until 2008. The primary endpoint was stroke death, cardiovascular death (CVD), or all-cause death during a 14-year mean follow-up, and the secondary endpoint was first atrial fibrillation (AF) event in subjects without self-reported heart diseases or AF at baseline. Compared with subjects without SVPCs, the multivariate-adjusted hazard ratios (HRs) [95% confidence interval (CI)] of stroke death, CVD, and all-cause death in subjects with SVPCs were 1.24 (0.98-1.56) for men and 1.63 (1.30-2.05) for women, 1.22 (1.04-1.44) for men and 1.48 (1.25-1.74) for women, and 1.08 (0.99-1.18) for men and 1.21 (1.09-1.34) for women, respectively. Atrial fibrillation occurred in 386 subjects during the follow-up (1.05/1000 person-years). The presence of SVPCs at baseline was the significant predictor of AF onset [HRs (95% CI): 4.87 (3.61-6.57) for men and 3.87 (2.69-5.57) for women]. Propensity score matched analyses also revealed the presence of SVPCs was significantly associated with increased risks of AF incidence and CVD even after adjusting the potential confounders. CONCLUSION: The presence of SVPCs in 12-lead electrocardiograms was a strong predictor of AF development, and associated with increased risk of CVD in general population. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: The long-term prognosis of subjects with supraventricular premature complexes (SVPCs) remains unclear in the general population. The aim of this study was to examine the prognostic significance of SVPCs in community-based health checkups. METHODS AND RESULTS: We assessed 63 197 individuals (mean age, 58.8 ± 9.9 years; 67.6% women) who participated in annual community-based health checkups in 1993 and were followed until 2008. The primary endpoint was stroke death, cardiovascular death (CVD), or all-cause death during a 14-year mean follow-up, and the secondary endpoint was first atrial fibrillation (AF) event in subjects without self-reported heart diseases or AF at baseline. Compared with subjects without SVPCs, the multivariate-adjusted hazard ratios (HRs) [95% confidence interval (CI)] of stroke death, CVD, and all-cause death in subjects with SVPCs were 1.24 (0.98-1.56) for men and 1.63 (1.30-2.05) for women, 1.22 (1.04-1.44) for men and 1.48 (1.25-1.74) for women, and 1.08 (0.99-1.18) for men and 1.21 (1.09-1.34) for women, respectively. Atrial fibrillation occurred in 386 subjects during the follow-up (1.05/1000 person-years). The presence of SVPCs at baseline was the significant predictor of AF onset [HRs (95% CI): 4.87 (3.61-6.57) for men and 3.87 (2.69-5.57) for women]. Propensity score matched analyses also revealed the presence of SVPCs was significantly associated with increased risks of AF incidence and CVD even after adjusting the potential confounders. CONCLUSION: The presence of SVPCs in 12-lead electrocardiograms was a strong predictor of AF development, and associated with increased risk of CVD in general population. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: M Yldau van der Ende; Joylene E Siland; Harold Snieder; Pim van der Harst; Michiel Rienstra Journal: Clin Cardiol Date: 2017-06-12 Impact factor: 2.882
Authors: Kaylin T Nguyen; Eric Vittinghoff; Thomas A Dewland; Jonathan W Dukes; Elsayed Z Soliman; Phyllis K Stein; John S Gottdiener; Alvaro Alonso; Lin Y Chen; Bruce M Psaty; Susan R Heckbert; Gregory M Marcus Journal: J Am Heart Assoc Date: 2017-08-03 Impact factor: 5.501
Authors: Jithin K Sajeev; Anoop N Koshy; Helen Dewey; Jonathan M Kalman; Kevin Rajakariar; Mae C Tan; Maryann Street; Louise Roberts; Jennifer C Cooke; Michael Wong; Tanya Frost; Andrew W Teh Journal: BMJ Open Date: 2019-07-31 Impact factor: 2.692