Literature DB >> 25356858

A facile access to 4-substituted-2-naphthols via a tandem Friedel-Crafts reaction: a β-chlorovinyl ketone pathway.

Hun Young Kim1, Kyungsoo Oh.   

Abstract

A one-pot synthesis of 2-naphthol derivatives is accomplished using a tandem Friedel-Crafts reaction sequence. The developed methodology allows for a concomitant construction of up to three C-C bonds between readily available alkynes and phenylacetyl chloride derivatives by an intermolecular Friedel-Crafts acylation of alkynes followed by an intramolecular Friedel-Crafts alkylation of β-chlorovinyl ketone intermediates.

Entities:  

Year:  2014        PMID： 25356858     DOI： 10.1021/ol502951v

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones.

Authors:  John L Woodard; Andrew C Huntsman; Pratiq A Patel; Hee-Byung Chai; Ragu Kanagasabai; Soumendrakrishna Karmahapatra; Alexandria N Young; Yulin Ren; Malcolm S Cole; Denisse Herrera; Jack C Yalowich; A Douglas Kinghorn; Joanna E Burdette; James R Fuchs
Journal:  Bioorg Med Chem       Date:  2018-03-23       Impact factor: 3.641

2.  Intramolecular Vinylation of Aryl Rings by Vinyl Cations.

Authors:  Jian Fang; Matthias Brewer
Journal:  Org Lett       Date:  2018-11-14       Impact factor: 6.005

3.  One-Pot Synthesis of (Z)-β-Halovinyl Ketones via the Cascade of Sonogashira Coupling and Hydrohalogenation.

Authors:  Fa-Jie Chen; Zhenguo Hua; Jianhui Chen; Jiajia Chen; Daesung Lee; Yuanzhi Xia
Journal:  Front Chem       Date:  2021-04-22       Impact factor: 5.221
  3 in total

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