Naomi R Goldberg1, Douglas A Jabs1,2,3,4, Jacqueline Busingye1. 1. a Departments of Ophthalmology . 2. b Departments of Medicine . 3. c The Institute for Translational Epidemiology, The Icahn School of Medicine at Mount Sinai , New York , NY , and. 4. d The Center for Clinical Trials, The Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health , Baltimore , MD.
Abstract
PURPOSE: To characterize nodular lesions of the retina and optic nerve with spectral-domain optical coherence tomography (SD-OCT) in patients with sarcoidosis. METHODS: This is a retrospective series of 6 eyes from 5 patients with an established diagnosis of sarcoidosis, with clinically detected nodules of the optic nerve or retina. All lesions were imaged with fundus photography and SD-OCT on presentation, and followed with serial imaging after treatment with corticosteroids and/or immunomodulatory therapy. RESULTS: Spectral OCT through the lesions revealed nodular hyperreflective processes obscuring the retinal layers or optic cup, with local structural changes, including subretinal and intraretinal fluid. After treatment with corticosteroids and/or immunosuppression in 4 followed patients, all lesions regressed with improvement in associated structural changes, but did not entirely disappear. CONCLUSIONS: Spectral OCT can be useful in identifying lesion morphology and location, and in tracking the response to treatment in eyes with posterior-segment nodules, presumably secondary to sarcoidosis.
PURPOSE: To characterize nodular lesions of the retina and optic nerve with spectral-domain optical coherence tomography (SD-OCT) in patients with sarcoidosis. METHODS: This is a retrospective series of 6 eyes from 5 patients with an established diagnosis of sarcoidosis, with clinically detected nodules of the optic nerve or retina. All lesions were imaged with fundus photography and SD-OCT on presentation, and followed with serial imaging after treatment with corticosteroids and/or immunomodulatory therapy. RESULTS: Spectral OCT through the lesions revealed nodular hyperreflective processes obscuring the retinal layers or optic cup, with local structural changes, including subretinal and intraretinal fluid. After treatment with corticosteroids and/or immunosuppression in 4 followed patients, all lesions regressed with improvement in associated structural changes, but did not entirely disappear. CONCLUSIONS: Spectral OCT can be useful in identifying lesion morphology and location, and in tracking the response to treatment in eyes with posterior-segment nodules, presumably secondary to sarcoidosis.
Authors: Betty A Situ; Susan J Streit; Timothy C Tran; Jim H Nomura; Simon R Bababeygy; Damien C Rodger Journal: Am J Ophthalmol Case Rep Date: 2020-07-11