Literature DB >> 25355893

Regulation of influenza A virus nucleoprotein oligomerization by phosphorylation.

Lauren Turrell1, Edward C Hutchinson1, Frank T Vreede2, Ervin Fodor2.   

Abstract

In the influenza virus ribonucleoprotein complex, the oligomerization of the nucleoprotein is mediated by an interaction between the tail-loop of one molecule and the groove of the neighboring molecule. In this study, we show that phosphorylation of a serine residue (S165) within the groove of influenza A virus nucleoprotein inhibits oligomerization and, consequently, ribonucleoprotein activity and viral growth. We propose that nucleoprotein oligomerization in infected cells is regulated by reversible phosphorylation.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25355893      PMCID： PMC4300657          DOI： 10.1128/JVI.02332-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  18 in total

1.  Oligomerization of the influenza virus nucleoprotein: identification of positive and negative sequence elements.

Authors:  D Elton; E Medcalf; K Bishop; P Digard
Journal:  Virology       Date:  1999-07-20       Impact factor: 3.616

2.  Functional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities.

Authors:  Wai-Hon Chan; Andy Ka-Leung Ng; Nicole C Robb; Mandy Ka-Han Lam; Paul Kay-Sheung Chan; Shannon Wing-Ngor Au; Jia-Huai Wang; Ervin Fodor; Pang-Chui Shaw
Journal:  J Virol       Date:  2010-05-12       Impact factor: 5.103

3.  A DNA transfection system for generation of influenza A virus from eight plasmids.

Authors:  E Hoffmann; G Neumann; Y Kawaoka; G Hobom; R G Webster
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

Review 4.  The influenza virus RNA synthesis machine: advances in its structure and function.

Authors:  Patricia Resa-Infante; Núria Jorba; Rocio Coloma; Juan Ortin
Journal:  RNA Biol       Date:  2011-03-01       Impact factor: 4.652

5.  Oligomerization paths of the nucleoprotein of influenza A virus.

Authors:  B Tarus; O Bakowiez; S Chenavas; L Duchemin; L F Estrozi; C Bourdieu; N Lejal; J Bernard; M Moudjou; C Chevalier; B Delmas; R W H Ruigrok; C Di Primo; A Slama-Schwok
Journal:  Biochimie       Date:  2011-11-29       Impact factor: 4.079

6.  The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA.

Authors:  Qiaozhen Ye; Robert M Krug; Yizhi Jane Tao
Journal:  Nature       Date:  2006-12-06       Impact factor: 49.962

7.  Rescue of influenza A virus from recombinant DNA.

Authors:  E Fodor; L Devenish; O G Engelhardt; P Palese; G G Brownlee; A García-Sastre
Journal:  J Virol       Date:  1999-11       Impact factor: 5.103

Review 8.  The RNA polymerase of influenza a virus: mechanisms of viral transcription and replication.

Authors:  E Fodor
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9.  NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome.

Authors:  Nicole C Robb; Matt Smith; Frank T Vreede; Ervin Fodor
Journal:  J Gen Virol       Date:  2009-03-04       Impact factor: 3.891

10.  Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design.

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Journal:  FASEB J       Date:  2008-07-09       Impact factor: 5.191
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  22 in total

1.  Phosphorylation controls the nuclear-cytoplasmic shuttling of influenza A virus nucleoprotein.

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Journal:  J Virol       Date:  2015-03-18       Impact factor: 5.103

2.  Effect of Phosphorylation of CM2 Protein on Influenza C Virus Replication.

Authors:  Takanari Goto; Yoshitaka Shimotai; Yoko Matsuzaki; Yasushi Muraki; Ri Sho; Kanetsu Sugawara; Seiji Hongo
Journal:  J Virol       Date:  2017-10-27       Impact factor: 5.103

3.  Phosphoproteome Analysis of Cells Infected with Adapted and Nonadapted Influenza A Virus Reveals Novel Pro- and Antiviral Signaling Networks.

Authors:  Axel Weber; Sharmistha Dam; Vera V Saul; Irina Kuznetsova; Christin Müller; Karin Fritz-Wolf; Katja Becker; Uwe Linne; Hongbo Gu; Matthew P Stokes; Stephan Pleschka; Michael Kracht; M Lienhard Schmitz
Journal:  J Virol       Date:  2019-06-14       Impact factor: 5.103

4.  Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals.

Authors:  Chenxi Wang; Runkang Qu; Yanan Zong; Chao Qin; Litao Liu; Xiaoyi Gao; Honglei Sun; Yipeng Sun; Kin-Chow Chang; Rui Zhang; Jinhua Liu; Juan Pu
Journal:  PLoS Pathog       Date:  2022-07-06       Impact factor: 7.464

5.  Interactions between Influenza A Virus Nucleoprotein and Gene Segment Untranslated Regions Facilitate Selective Modulation of Viral Gene Expression.

Authors:  Meghan Diefenbacher; Timothy J C Tan; David L V Bauer; Beth M Stadtmueller; Nicholas C Wu; Christopher B Brooke
Journal:  J Virol       Date:  2022-04-25       Impact factor: 6.549

6.  Ubiquitination Upregulates Influenza Virus Polymerase Function.

Authors:  James Kirui; Arindam Mondal; Andrew Mehle
Journal:  J Virol       Date:  2016-11-14       Impact factor: 5.103

Review 7.  Structure and Function of the Influenza Virus Transcription and Replication Machinery.

Authors:  Ervin Fodor; Aartjan J W Te Velthuis
Journal:  Cold Spring Harb Perspect Med       Date:  2020-09-01       Impact factor: 6.915

Review 8.  Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis.

Authors:  Aartjan J W Te Velthuis; Ervin Fodor
Journal:  Nat Rev Microbiol       Date:  2016-07-11       Impact factor: 60.633

9.  Phosphorylation at the homotypic interface regulates nucleoprotein oligomerization and assembly of the influenza virus replication machinery.

Authors:  Arindam Mondal; Gregory K Potts; Anthony R Dawson; Joshua J Coon; Andrew Mehle
Journal:  PLoS Pathog       Date:  2015-04-13       Impact factor: 6.823

10.  Time-Resolved Visualisation of Nearly-Native Influenza A Virus Progeny Ribonucleoproteins and Their Individual Components in Live Infected Cells.

Authors:  Sergiy Avilov; Julie Magnus; Stephen Cusack; Nadia Naffakh
Journal:  PLoS One       Date:  2016-03-15       Impact factor: 3.240
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