Régis Lopez1, Isabelle Jaussent1, Yves Dauvilliers2. 1. From the National Reference Network for Narcolepsy (R.L., Y.D.), Sleep-Wake Disorders Center, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier; INSERM (R.L., I.J., Y.D.), U1061, Montpellier; and Université Montpellier 1 (R.L., I.J., Y.D.), Montpellier, France. 2. From the National Reference Network for Narcolepsy (R.L., Y.D.), Sleep-Wake Disorders Center, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier; INSERM (R.L., I.J., Y.D.), U1061, Montpellier; and Université Montpellier 1 (R.L., I.J., Y.D.), Montpellier, France. ydauvilliers@yahoo.fr.
Abstract
OBJECTIVE: To objectively measure daytime sleepiness and to assess for clinical and polysomnographic determinants of mean sleep latency in adult patients with somnambulism (sleepwalking [SW]) or sleep terrors (ST) compared with controls. METHODS: Thirty drug-free adult patients with primary SW or ST, and age-, sex-, and body mass index-matched healthy controls underwent a standardized clinical interview, completed questionnaires including the Epworth Sleepiness Scale, and underwent one night of video polysomnography followed by the Multiple Sleep Latency Test (MSLT). RESULTS: Excessive daytime sleepiness defined as Epworth Sleepiness Scale score >10 was reported in 66.7% of patients and 6.7% of controls. The temporal pattern of sleep latencies in individual MSLT trials differed between patients and controls, with progressive increased sleep latency in patients across the trials in contrast to a "U curve" for controls. We did not find between-group differences regarding the mean sleep latency on the 5 MSLT trials, but did observe reduced sleep latencies in patients for the first 2 trials. Despite increased slow-wave sleep disruptions found in patients (i.e, more micro-arousals and hypersynchronous high-voltage delta waves arousals), we did not find polysomnographic characteristic differences when comparing sleepy patients for either subjective or objective daytime sleepiness on the MSLT compared with alert patients. CONCLUSION: Excessive daytime sleepiness is a common complaint in subjects with SW or ST and shorter sleep latencies in the early morning hours. Despite an increased slow-wave sleep fragmentation found in these patients, we did not identify any association with the level of daytime sleepiness.
OBJECTIVE: To objectively measure daytime sleepiness and to assess for clinical and polysomnographic determinants of mean sleep latency in adult patients with somnambulism (sleepwalking [SW]) or sleep terrors (ST) compared with controls. METHODS: Thirty drug-free adult patients with primary SW or ST, and age-, sex-, and body mass index-matched healthy controls underwent a standardized clinical interview, completed questionnaires including the Epworth Sleepiness Scale, and underwent one night of video polysomnography followed by the Multiple Sleep Latency Test (MSLT). RESULTS:Excessive daytime sleepiness defined as Epworth Sleepiness Scale score >10 was reported in 66.7% of patients and 6.7% of controls. The temporal pattern of sleep latencies in individual MSLT trials differed between patients and controls, with progressive increased sleep latency in patients across the trials in contrast to a "U curve" for controls. We did not find between-group differences regarding the mean sleep latency on the 5 MSLT trials, but did observe reduced sleep latencies in patients for the first 2 trials. Despite increased slow-wave sleep disruptions found in patients (i.e, more micro-arousals and hypersynchronous high-voltage delta waves arousals), we did not find polysomnographic characteristic differences when comparing sleepy patients for either subjective or objective daytime sleepiness on the MSLT compared with alert patients. CONCLUSION:Excessive daytime sleepiness is a common complaint in subjects with SW or ST and shorter sleep latencies in the early morning hours. Despite an increased slow-wave sleep fragmentation found in these patients, we did not identify any association with the level of daytime sleepiness.
Authors: Anna Castelnovo; Brady A Riedner; Richard F Smith; Giulio Tononi; Melanie Boly; Ruth M Benca Journal: Sleep Date: 2016-10-01 Impact factor: 5.849
Authors: Panagis Drakatos; Lucy Marples; Rexford Muza; Sean Higgins; Nadia Gildeh; Raluca Macavei; Eptehal M Dongol; Alexander Nesbitt; Ivana Rosenzweig; Elaine Lyons; Grainne d'Ancona; Joerg Steier; Adrian J Williams; Brian D Kent; Guy Leschziner Journal: Sleep Med Date: 2018-04-10 Impact factor: 3.492