Literature DB >> 2535482

Primary structure of human milk nona- and decasaccharides determined by a combination of fast atom bombardment mass spectrometry and 1H-/13C-nuclear magnetic resonance spectroscopy. Evidence for a new core structure, iso-lacto-N-octaose.

G Strecker1, J M Wieruszeski, J C Michalski, J Montreuil.   

Abstract

The structure of a nonasaccharide and of two decasaccharides isolated from human milk has been investigated by using methylation, fast atom bombardment mass spectrometry and 1H-/13C-nuclear magnetic resonance spectroscopy. The structures of these oligosaccharides were: trifucosyllacto-N-hexaose; Fuc alpha 1-2Gal beta 1-3(Fuc alpha 1-4)GlcNAc beta 1-3[Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-6]Gal beta 1-4Glc, difucosyllacto-N-octaoses; Gal beta 1-3(Fuc alpha 1-4)GlcNAc beta 1-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-6[Gal beta 1-3GlcNAc beta 1-3]Gal beta 1-4Glc and Gal beta 1-3GlcNAc beta 1-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-6[Fuc alpha 1-3 Gal beta 1-3GlcNAc beta 1-3]Gal beta 1-4Glc. The two decasaccharides possess a new type of core structure proposed to be named iso-lacto-N-octaose.

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Year:  1989        PMID： 2535482     DOI： 10.1007/bf01050646

Source DB:  PubMed          Journal:  Glycoconj J        ISSN： 0282-0080            Impact factor:   2.916


  4 in total

1.  Oligosaccharides from faeces of a blood-group B, breast-fed infant.

Authors:  H Sabharwal; B Nilsson; M A Chester; F Lindh; G Grönberg; S Sjöblad; A Lundblad
Journal:  Carbohydr Res       Date:  1988-07-15       Impact factor: 2.104

2.  Assignment of the 1H- and 13C-NMR spectra of eight oligosaccharides of the lacto-N-tetraose and neotetraose series.

Authors:  G Strecker; J M Wieruszeski; J C Michalski; J Montreuil
Journal:  Glycoconj J       Date:  1989       Impact factor: 2.916

3.  Scope and limitations of rotating-frame nuclear Overhauser enhancement spectroscopy applied to oligosaccharides.

Authors:  J Breg; D Romijn; J F Vliegenthart; G Strecker; J Montreuil
Journal:  Carbohydr Res       Date:  1988-11-15       Impact factor: 2.104

4.  Fucose-containing oligosaccharides from human milk from a donor of blood group 0 Le(a) nonsecretor.

Authors:  R Bruntz; U Dabrowski; J Dabrowski; A Ebersold; J Peter-Katalinić; H Egge
Journal:  Biol Chem Hoppe Seyler       Date:  1988-04
  4 in total
  6 in total

1.  Structural analysis of underivatized neutral human milk oligosaccharides in the negative ion mode by nano-electrospray MS(n) (part 1: methodology).

Authors:  Anja Pfenninger; Michael Karas; Berndt Finke; Bernd Stahl
Journal:  J Am Soc Mass Spectrom       Date:  2002-11       Impact factor: 3.109

2.  Mass spectrometric detection of multiple extended series of neutral highly fucosylated N-acetyllactosamine oligosaccharides in human milk.

Authors:  Anja Pfenninger; Shiu-Yung Chan; Michael Karas; Berndt Finke; Bernd Stahl; Catherine E Costello
Journal:  Int J Mass Spectrom       Date:  2008-09-16       Impact factor: 1.986

3.  Variations of neutral oligosaccharides and lactose in human milk during the feeding.

Authors:  S Thurl; J Henker; H Taut; K Tovar; G Sawatzki
Journal:  Z Ernahrungswiss       Date:  1993-12

Review 4.  Structures and application of oligosaccharides in human milk.

Authors:  Akira Kobata
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2010       Impact factor: 3.493

Review 5.  Challenges and Pitfalls in Human Milk Oligosaccharide Analysis.

Authors:  Sander S van Leeuwen
Journal:  Nutrients       Date:  2019-11-06       Impact factor: 5.717

Review 6.  Human Milk Oligosaccharides (HMOS): Structure, Function, and Enzyme-Catalyzed Synthesis.

Authors:  Xi Chen
Journal:  Adv Carbohydr Chem Biochem       Date:  2015-11-11       Impact factor: 3.714
  6 in total

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