Literature DB >> 25354467

Structure and specificity of FEN-1 from Methanopyrus kandleri.

Santosh Shah1, Pete Dunten, Amanda Stiteler, Chad K Park, Nancy C Horton.   

Abstract

DNA repair is fundamental to genome stability and is found in all three domains of life. However many archaeal species, such as Methanopyrus kandleri, contain only a subset of the eukaryotic nucleotide excision repair (NER) homologs, and those present often contain significant differences compared to their eukaryotic homologs. To clarify the role of the NER XPG-like protein Mk0566 from M. kandleri, its biochemical activity and three-dimensional structure were investigated. Both were found to be more similar to human FEN-1 than human XPG, suggesting a biological role in replication and long-patch base excision repair rather than in NER.
© 2014 Wiley Periodicals, Inc.

Entities:  

Keywords:  DNA nuclease; nucleotide excision repair; protein-DNA complex

Mesh：

Substances：

Year:  2014        PMID： 25354467      PMCID： PMC4270939          DOI： 10.1002/prot.24704

Source DB:  PubMed          Journal:  Proteins        ISSN： 0887-3585


  15 in total

1.  A comparison of eubacterial and archaeal structure-specific 5'-exonucleases.

Authors:  M W Kaiser; N Lyamicheva; W Ma; C Miller; B Neri; L Fors; V I Lyamichev
Journal:  J Biol Chem       Date:  1999-07-23       Impact factor: 5.157

Review 2.  Molecular mechanisms of mammalian global genome nucleotide excision repair.

Authors:  Ludovic C J Gillet; Orlando D Schärer
Journal:  Chem Rev       Date:  2006-02       Impact factor: 60.622

3.  Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.

Authors:  D J Hosfield; C D Mol; B Shen; J A Tainer
Journal:  Cell       Date:  1998-10-02       Impact factor: 41.582

Review 4.  Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.

Authors:  Binghui Shen; Purnima Singh; Ren Liu; Junzhuan Qiu; Li Zheng; L David Finger; Steve Alas
Journal:  Bioessays       Date:  2005-07       Impact factor: 4.345

5.  Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair.

Authors:  Brian R Chapados; David J Hosfield; Seungil Han; Junzhuan Qiu; Biana Yelent; Binghui Shen; John A Tainer
Journal:  Cell       Date:  2004-01-09       Impact factor: 41.582

Review 6.  Lessons learned from DNA repair defective syndromes.

Authors:  Kai-Martin Thoms; Christiane Kuschal; Steffen Emmert
Journal:  Exp Dermatol       Date:  2007-06       Impact factor: 3.960

7.  Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1.

Authors:  D J Hosfield; G Frank; Y Weng; J A Tainer; B Shen
Journal:  J Biol Chem       Date:  1998-10-16       Impact factor: 5.157

8.  The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis.

Authors:  L David Finger; M Suzette Blanchard; Carla A Theimer; Blanka Sengerová; Purnima Singh; Valerie Chavez; Fei Liu; Jane A Grasby; Binghui Shen
Journal:  J Biol Chem       Date:  2009-06-11       Impact factor: 5.157

9.  The characterization of a mammalian DNA structure-specific endonuclease.

Authors:  J J Harrington; M R Lieber
Journal:  EMBO J       Date:  1994-03-01       Impact factor: 11.598

10.  Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity.

Authors:  Marcel Hohl; Isabelle Dunand-Sauthier; Lidija Staresincic; Pascale Jaquier-Gubler; Fabrizio Thorel; Mauro Modesti; Stuart G Clarkson; Orlando D Schärer
Journal:  Nucleic Acids Res       Date:  2007-04-22       Impact factor: 16.971
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