Literature DB >> 25354393

The multiple roles of sGP in Ebola pathogenesis.

Marc-Antoine de La Vega1, Gary Wong, Gary P Kobinger, Xiangguo Qiu.   

Abstract

Ebola causes severe hemorrhagic fever in humans and nonhuman primates, and there are currently no approved therapeutic countermeasures. The virulence of Ebola virus (EBOV) may be partially attributed to the secreted glycoprotein (sGP), which is the main product transcribed from its GP gene. sGP is secreted from infected cells and can be readily detected in the serum of EBOV-infected hosts. This review summarizes the multiple roles that sGP may play during infection and highlights the implications for the future design of vaccines and treatments.

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Year:  2015        PMID： 25354393      PMCID： PMC4287119          DOI： 10.1089/vim.2014.0068

Source DB:  PubMed          Journal:  Viral Immunol        ISSN： 0882-8245            Impact factor:   2.257


  63 in total

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Journal:  Nat Med       Date:  2000-08       Impact factor: 53.440

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Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-12       Impact factor: 11.205

3.  Ebola virus glycoprotein GP is not cytotoxic when expressed constitutively at a moderate level.

Authors:  Nathalie Alazard-Dany; Valentina Volchkova; Olivier Reynard; Caroline Carbonnelle; Olga Dolnik; Michèle Ottmann; Alexander Khromykh; Viktor E Volchkov
Journal:  J Gen Virol       Date:  2006-05       Impact factor: 3.891

4.  Modified HIV envelope proteins with enhanced binding to neutralizing monoclonal antibodies.

Authors:  Sang-Moo Kang; Fu Shi Quan; Chunzi Huang; Lizheng Guo; Ling Ye; Chinglai Yang; Richard W Compans
Journal:  Virology       Date:  2005-01-05       Impact factor: 3.616

5.  DNA vaccines expressing either the GP or NP genes of Ebola virus protect mice from lethal challenge.

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Journal:  Virology       Date:  1998-06-20       Impact factor: 3.616

6.  Antigenic subversion: a novel mechanism of host immune evasion by Ebola virus.

Authors:  Gopi S Mohan; Wenfang Li; Ling Ye; Richard W Compans; Chinglai Yang
Journal:  PLoS Pathog       Date:  2012-12-13       Impact factor: 6.823

7.  PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration.

Authors:  Ganta Vijay Chaitanya; Alexander J Steven; Phanithi Prakash Babu
Journal:  Cell Commun Signal       Date:  2010-12-22       Impact factor: 5.712

8.  Ebola haemorrhagic fever outbreak in Masindi District, Uganda: outbreak description and lessons learned.

Authors:  Matthias Borchert; Imaam Mutyaba; Maria D Van Kerkhove; Julius Lutwama; Henry Luwaga; Geoffrey Bisoborwa; John Turyagaruka; Patricia Pirard; Nestor Ndayimirije; Paul Roddy; Patrick Van Der Stuyft
Journal:  BMC Infect Dis       Date:  2011-12-28       Impact factor: 3.090

Review 9.  The secret life of viral entry glycoproteins: moonlighting in immune evasion.

Authors:  Jonathan D Cook; Jeffrey E Lee
Journal:  PLoS Pathog       Date:  2013-05-16       Impact factor: 6.823

10.  Ebola virus RNA editing depends on the primary editing site sequence and an upstream secondary structure.

Authors:  Masfique Mehedi; Thomas Hoenen; Shelly Robertson; Stacy Ricklefs; Michael A Dolan; Travis Taylor; Darryl Falzarano; Hideki Ebihara; Stephen F Porcella; Heinz Feldmann
Journal:  PLoS Pathog       Date:  2013-10-17       Impact factor: 6.823
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  40 in total

1.  Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability.

Authors:  Xuelian Zhao; Katie A Howell; Shihua He; Jennifer M Brannan; Anna Z Wec; Edgar Davidson; Hannah L Turner; Chi-I Chiang; Lin Lei; J Maximilian Fels; Hong Vu; Sergey Shulenin; Ashley N Turonis; Ana I Kuehne; Guodong Liu; Mi Ta; Yimeng Wang; Christopher Sundling; Yongli Xiao; Jennifer S Spence; Benjamin J Doranz; Frederick W Holtsberg; Andrew B Ward; Kartik Chandran; John M Dye; Xiangguo Qiu; Yuxing Li; M Javad Aman
Journal:  Cell       Date:  2017-05-18       Impact factor: 41.582

Review 2.  The structural basis for filovirus neutralization by monoclonal antibodies.

Authors:  Liam B King; Brandyn R West; Sharon L Schendel; Erica Ollmann Saphire
Journal:  Curr Opin Immunol       Date:  2018-06-22       Impact factor: 7.486

3.  Ebolavirus evolves in human to minimize the detection by immune cells by accumulating adaptive mutations.

Authors:  Arunachalam Ramaiah; Vaithilingaraja Arumugaswami
Journal:  Virusdisease       Date:  2016-02-22

4.  Overexpression of Ebola virus envelope GP1 protein.

Authors:  Zhongcheng Zou; John Misasi; Nancy Sullivan; Peter D Sun
Journal:  Protein Expr Purif       Date:  2017-04-27       Impact factor: 1.650

5.  Rapid detection of an Ebola biomarker with optical microring resonators.

Authors:  Abraham J Qavi; Krista Meserve; M Javad Aman; Hong Vu; Larry Zeitlin; John M Dye; Jeffrey W Froude; Daisy W Leung; Lan Yang; Frederick W Holtsberg; Ryan C Bailey; Gaya K Amarasinghe
Journal:  Cell Rep Methods       Date:  2022-06-08

Review 6.  Anti-Ebola therapies based on monoclonal antibodies: current state and challenges ahead.

Authors:  Everardo González-González; Mario Moisés Alvarez; Alan Roberto Márquez-Ipiña; Grissel Trujillo-de Santiago; Luis Mario Rodríguez-Martínez; Nasim Annabi; Ali Khademhosseini
Journal:  Crit Rev Biotechnol       Date:  2015-11-26       Impact factor: 8.429

7.  Inhibition of Ebola virus glycoprotein-mediated cytotoxicity by targeting its transmembrane domain and cholesterol.

Authors:  Moritz Hacke; Patrik Björkholm; Andrea Hellwig; Patricia Himmels; Carmen Ruiz de Almodóvar; Britta Brügger; Felix Wieland; Andreas M Ernst
Journal:  Nat Commun       Date:  2015-07-09       Impact factor: 14.919

8.  Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop.

Authors:  Charles D Murin; Jessica F Bruhn; Zachary A Bornholdt; Jeffrey Copps; Robyn Stanfield; Andrew B Ward
Journal:  Cell Rep       Date:  2018-09-04       Impact factor: 9.423

9.  Human Ebola virus infection in West Africa: a review of available therapeutic agents that target different steps of the life cycle of Ebola virus.

Authors:  Kang Yiu Lai; Wing Yiu George Ng; Fan Fanny Cheng
Journal:  Infect Dis Poverty       Date:  2014-11-28       Impact factor: 4.520

Review 10.  Ebolavirus comparative genomics.

Authors:  Se-Ran Jun; Michael R Leuze; Intawat Nookaew; Edward C Uberbacher; Miriam Land; Qian Zhang; Visanu Wanchai; Juanjuan Chai; Morten Nielsen; Thomas Trolle; Ole Lund; Gregory S Buzard; Thomas D Pedersen; Trudy M Wassenaar; David W Ussery
Journal:  FEMS Microbiol Rev       Date:  2015-07-14       Impact factor: 16.408
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