Structural brain-imaging findings in affective disorders: an overview.

In recent years, numerous reports of structural brain abnormalities found with computerized tomography (CT) scans in affective disorders (e.g., major depression, bipolar disorder) have been published. More currently, magnetic resonance imaging (MRI) studies have provided additional data on brain structure in affective disorders. In this article, the various CT and MRI findings in affective disorders are reviewed, and the clinical and research relevance of those neuroanatomical findings are presented and discussed.