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Literature DB >> 25354219

How can we improve oral contraceptive success in obese women?

Abstract

A rapid increase in obesity rates worldwide further underscores the importance of better understanding the pharmacokinetic alterations in this sub-population and the subsequent effects on pharmacotherapeutics. Pharmacokinetics of contraceptive steroids is altered in obese oral contraceptive users, which may in turn impact efficacy. Our study has identified several dosing strategies that offset these pharmacokinetic changes and may improve effectiveness for obese oral contraception users.

Entities: Chemical Disease Species

Keywords: drug failure; obesity; oral contraception; pharmacokinetics; steroidal hormones

Mesh：

Substances：
Contraceptives, Oral

Year: 2014 PMID： 25354219 PMCID： PMC4581527 DOI： 10.1586/17512433.2015.974558

Source DB: PubMed Journal: Expert Rev Clin Pharmacol ISSN： 1751-2433 Impact factor: 5.045

Keyword Cloud
References

15 in total

1. Disparities in rates of unintended pregnancy in the United States, 1994 and 2001.

Authors: Lawrence B Finer; Stanley K Henshaw
Journal: Perspect Sex Reprod Health Date: 2006-06

2. Oral contraceptive effectiveness according to body mass index, weight, age, and other factors.

Authors: Jürgen C Dinger; Maureen Cronin; Sabine Möhner; Ilka Schellschmidt; Thai Do Minh; Carolyn Westhoff
Journal: Am J Obstet Gynecol Date: 2009-05-30 Impact factor: 8.661

3. Pharmacokinetics of a combined oral contraceptive in obese and normal-weight women.

Authors: Carolyn L Westhoff; Anupama H Torgal; Elizabeth R Mayeda; Malcolm C Pike; Frank Z Stanczyk
Journal: Contraception Date: 2010-02-20 Impact factor: 3.375

4. Unintended pregnancy and taxpayer spending.

Authors: Emily Monea; Adam Thomas
Journal: Perspect Sex Reprod Health Date: 2011-05-19

5. Efflux transport is an important determinant of ethinylestradiol glucuronide and ethinylestradiol sulfate pharmacokinetics.

Authors: Maciej J Zamek-Gliszczynski; Jeffrey S Day; Kathleen M Hillgren; Diane L Phillips
Journal: Drug Metab Dispos Date: 2011-06-27 Impact factor: 3.922

How can we improve oral contraceptive success in obese women?

1. Disparities in rates of unintended pregnancy in the United States, 1994 and 2001.

2. Oral contraceptive effectiveness according to body mass index, weight, age, and other factors.

3. Pharmacokinetics of a combined oral contraceptive in obese and normal-weight women.

4. Unintended pregnancy and taxpayer spending.

5. Efflux transport is an important determinant of ethinylestradiol glucuronide and ethinylestradiol sulfate pharmacokinetics.

6. Effectiveness of oral contraceptive pills in a large U.S. cohort comparing progestogen and regimen.

7. Use of contraception and use of family planning services in the United States: 1982-2002.

8. Body mass index, weight, and oral contraceptive failure risk.

9. Impact of obesity on oral contraceptive pharmacokinetics and hypothalamic-pituitary-ovarian activity.

Review 10. Effect of obesity on the pharmacokinetics of drugs in humans.