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Literature DB >> 25354106

Applying synthetic lethality for the selective targeting of cancer.

Donal P McLornan¹, Alan List, Ghulam J Mufti.

Abstract

Entities: Disease

Mesh：

Substances：

Year: 2014 PMID： 25354106 DOI： 10.1056/NEJMra1407390

Source DB: PubMed Journal: N Engl J Med ISSN： 0028-4793 Impact factor: 91.245

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84 in total

1. Massively parallel high-order combinatorial genetics in human cells.

Authors: Alan S L Wong; Gigi C G Choi; Allen A Cheng; Oliver Purcell; Timothy K Lu
Journal: Nat Biotechnol Date: 2015-08-17 Impact factor: 54.908

2. USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.

Authors: Julia M Fraile; Eusebio Manchado; Amaia Lujambio; Víctor Quesada; Diana Campos-Iglesias; Thomas R Webb; Scott W Lowe; Carlos López-Otín; José M P Freije
Journal: J Biol Chem Date: 2017-02-01 Impact factor: 5.157

3. Genetic interactions improve models of quantitative traits.

Authors: Anna L Tyler; Gregory W Carter
Journal: Nat Genet Date: 2017-03-30 Impact factor: 38.330

4. Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer.

Authors: Nicholas R Perkons; Omar Johnson; Gabrielle Pilla; Enri Profka; Michael Mercadante; Daniel Ackerman; Terence P F Gade
Journal: Clin Cancer Res Date: 2020-06-04 Impact factor: 12.531

5. Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C.

Authors: Alexia T Kedves; Scott Gleim; Xiaoyou Liang; Dennis M Bonal; Frederic Sigoillot; Fred Harbinski; Sneha Sanghavi; Christina Benander; Elizabeth George; Prafulla C Gokhale; Quang-De Nguyen; Paul T Kirschmeier; Robert J Distel; Jeremy Jenkins; Michael S Goldberg; William C Forrester
Journal: J Clin Invest Date: 2017-11-13 Impact factor: 14.808

10. Using an RNAi Signature Assay To Guide the Design of Three-Drug-Conjugated Nanoparticles with Validated Mechanisms, In Vivo Efficacy, and Low Toxicity.

Authors: Jonathan C Barnes; Peter M Bruno; Hung V-T Nguyen; Longyan Liao; Jenny Liu; Michael T Hemann; Jeremiah A Johnson
Journal: J Am Chem Soc Date: 2016-09-14 Impact factor: 15.419

Applying synthetic lethality for the selective targeting of cancer.

1. Massively parallel high-order combinatorial genetics in human cells.

2. USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.

3. Genetic interactions improve models of quantitative traits.

4. Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer.

5. Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C.

6. SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets.

7. CD4+ memory T cells infected with latent HIV-1 are susceptible to drugs targeting telomeres.

8. MicroRNA-based screens for synthetic lethal interactions with c-Myc.

9. A novel EZH2 inhibitor induces synthetic lethality and apoptosis in PBRM1-deficient cancer cells.

10. Using an RNAi Signature Assay To Guide the Design of Three-Drug-Conjugated Nanoparticles with Validated Mechanisms, In Vivo Efficacy, and Low Toxicity.