OBJECTIVES: We investigated the relationship between insulin resistance reflected by homeostasis model assessment (HOMA-IR) index and serum HbA1c levels of obese children. MATERIAL AND METHODS: This study included 70 obese and 60 normal weight healthy children between the ages of 3 and 15. Anthropometric measures and biochemical tests (fasting glucose, fasting insulin, HbA1c) were performed on all subjects. Plasma glucose levels were measured by the glucose oxidase method. Plasma insulin concentrations were measured by radioimmunoassay (RIA). HOMA-IR index was used to estimate insulin resistance. A cut-off HOMA-IR level of ≥2.5 was accepted. The HbA1c analysis was performed using high-pressure liquid chromatography. The statistical analysis was performed using SPSS 5. Student's unpaired t-test and the Mann-Whitney U test were used to determine statistical significance. RESULTS: Gender distribution did not reveal significant difference among the obese (F: 48.6%, M: 51.4%) and the non-obese (F: 46.7%, M: 53.3%) groups. The mean age value was significantly higher in the obese group (10.09 ± 3.09) (p > 0.005) than the non-obese group (8.31 ± 3.14) (p < 0.05). The mean value of body mass index (BMI) was 25.55 ± 4.3 in the obese group and 16.63 ± 2.3 in the non-obese group. The mean HOMA-IR values of obese group (2.84 ± 1.77) was significantly higher than the non-obese group (1.50 ± 0.95) (p < 0.005). Insulin resistance was significantly higher in the obese group. Subjects with HOMA-IR ≥2.5 levels in the obese group had significantly higher HbA1c values than those with HOMA-IR <2.5 levels. CONCLUSIONS: High HbA1c levels in obese children can be used as a screening tool to detect insulin sensitivity and resistance at an early stage.
OBJECTIVES: We investigated the relationship between insulin resistance reflected by homeostasis model assessment (HOMA-IR) index and serum HbA1c levels of obesechildren. MATERIAL AND METHODS: This study included 70 obese and 60 normal weight healthy children between the ages of 3 and 15. Anthropometric measures and biochemical tests (fasting glucose, fasting insulin, HbA1c) were performed on all subjects. Plasma glucose levels were measured by the glucose oxidase method. Plasma insulin concentrations were measured by radioimmunoassay (RIA). HOMA-IR index was used to estimate insulin resistance. A cut-off HOMA-IR level of ≥2.5 was accepted. The HbA1c analysis was performed using high-pressure liquid chromatography. The statistical analysis was performed using SPSS 5. Student's unpaired t-test and the Mann-Whitney U test were used to determine statistical significance. RESULTS: Gender distribution did not reveal significant difference among the obese (F: 48.6%, M: 51.4%) and the non-obese (F: 46.7%, M: 53.3%) groups. The mean age value was significantly higher in the obese group (10.09 ± 3.09) (p > 0.005) than the non-obese group (8.31 ± 3.14) (p < 0.05). The mean value of body mass index (BMI) was 25.55 ± 4.3 in the obese group and 16.63 ± 2.3 in the non-obese group. The mean HOMA-IR values of obese group (2.84 ± 1.77) was significantly higher than the non-obese group (1.50 ± 0.95) (p < 0.005). Insulin resistance was significantly higher in the obese group. Subjects with HOMA-IR ≥2.5 levels in the obese group had significantly higher HbA1c values than those with HOMA-IR <2.5 levels. CONCLUSIONS: High HbA1c levels in obesechildren can be used as a screening tool to detect insulin sensitivity and resistance at an early stage.
Authors: G Valerio; M R Licenziati; A Iannuzzi; A Franzese; P Siani; G Riccardi; P Rubba Journal: Nutr Metab Cardiovasc Dis Date: 2006-03-20 Impact factor: 4.222
Authors: Y Heianza; Y Arase; K Fujihara; H Tsuji; K Saito; S D Hsieh; S Kodama; H Shimano; N Yamada; S Hara; H Sone Journal: Diabet Med Date: 2012-10 Impact factor: 4.359
Authors: Ram Weiss; James Dziura; Tania S Burgert; William V Tamborlane; Sara E Taksali; Catherine W Yeckel; Karin Allen; Melinda Lopes; Mary Savoye; John Morrison; Robert S Sherwin; Sonia Caprio Journal: N Engl J Med Date: 2004-06-03 Impact factor: 91.245
Authors: S D Long; K O'Brien; K G MacDonald; N Leggett-Frazier; M S Swanson; W J Pories; J F Caro Journal: Diabetes Care Date: 1994-05 Impact factor: 19.112
Authors: Emily C Moody; Alejandra Cantoral; Marcela Tamayo-Ortiz; Ma Luisa Pizano-Zárate; Lourdes Schnaas; Itai Kloog; Emily Oken; Brent Coull; Andrea Baccarelli; Martha M Téllez-Rojo; Robert O Wright; Allan C Just Journal: JAMA Netw Open Date: 2019-12-02