| Literature DB >> 25352171 |
Marta Meazza1, Victor Ceban, Mateusz B Pitak, Simon J Coles, Ramon Rios.
Abstract
A novel catalytic enantioselective methodology based on synergistic catalysis is reported. The strategy involves: 1) the metal-Lewis-acid activation of alkylazaarenes, and 2) the secondary-amine activation of enals. Consequently, highly functionalized chiral alkylazaarenes were obtained in good yields and with reasonable stereoselectivity.Entities:
Keywords: Michael addition; alkyl azaarenes; iminium catalysis; palladium; synergistic catalysis
Year: 2014 PMID： 25352171 DOI： 10.1002/chem.201404565
Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236