| Literature DB >> 25351666 |
Alok Ranjan1, Ragini Yerande, Prasad B Wakchaure, Swapnil G Yerande, Dattatraya H Dethe.
Abstract
An intramolecular transition-metal-free base-mediated hydroamination of propargylamine with isothiocyanates has been achieved. This atom-economical, regioselective intramolecular 5-exo-dig cycloisomerization was utilized for the one-pot synthesis of diversely substituted imidazole-2-thione and spiro-cyclic imidazolidine-2-thione. The reaction goes to completion at room temperature via propargylthiourea and 65-97% isolated yields were obtained.Entities:
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Year: 2014 PMID： 25351666 DOI： 10.1021/ol502871r
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005