Literature DB >> 25349923

A mitochondria-targeted protonophoric uncoupler derived from fluorescein.

Stepan S Denisov1, Elena A Kotova, Egor Y Plotnikov, Artur A Tikhonov, Dmitry B Zorov, Galina A Korshunova, Yuri N Antonenko.   

Abstract

Linking decyl-triphenyl-phosphonium to fluorescein yields a fluorescent probe that accumulates in energized mitochondria, facilitates proton transfer across membranes and stimulates mitochondrial respiration. This features a mitochondria-targeted uncoupler, being of potential interest for therapeutic use against oxidative stress-related diseases.

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Year:  2014        PMID： 25349923     DOI： 10.1039/c4cc04996a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

Review 1.  Mitochondrial membrane potential.

Authors:  Ljubava D Zorova; Vasily A Popkov; Egor Y Plotnikov; Denis N Silachev; Irina B Pevzner; Stanislovas S Jankauskas; Valentina A Babenko; Savva D Zorov; Anastasia V Balakireva; Magdalena Juhaszova; Steven J Sollott; Dmitry B Zorov
Journal:  Anal Biochem       Date:  2017-07-12       Impact factor: 3.365

Review 2.  Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications.

Authors:  Jacek Zielonka; Joy Joseph; Adam Sikora; Micael Hardy; Olivier Ouari; Jeannette Vasquez-Vivar; Gang Cheng; Marcos Lopez; Balaraman Kalyanaraman
Journal:  Chem Rev       Date:  2017-06-27       Impact factor: 60.622

Review 3.  Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases.

Authors:  Stéphane Demine; Patricia Renard; Thierry Arnould
Journal:  Cells       Date:  2019-07-30       Impact factor: 6.600

4.  Alkyl vs. aryl modifications: a comparative study on modular modifications of triphenylphosphonium mitochondrial vectors.

Authors:  How Chee Ong; João T S Coimbra; Germain Kwek; Maria J Ramos; Bengang Xing; Pedro A Fernandes; Felipe García
Journal:  RSC Chem Biol       Date:  2021-08-25

5.  Fifty Years of Research on Protonophores: Mitochondrial Uncoupling As a Basis for Therapeutic Action.

Authors:  E A Kotova; Y N Antonenko
Journal:  Acta Naturae       Date:  2022 Jan-Mar       Impact factor: 2.204

6.  Carboranyl-Chlorin e6 as a Potent Antimicrobial Photosensitizer.

Authors:  Elena O Omarova; Pavel A Nazarov; Alexander M Firsov; Marina G Strakhovskaya; Anastasia Yu Arkhipova; Mikhail M Moisenovich; Igor I Agapov; Valentina A Ol'shevskaya; Andrey V Zaitsev; Valery N Kalinin; Elena A Kotova; Yuri N Antonenko
Journal:  PLoS One       Date:  2015-11-04       Impact factor: 3.240
  6 in total

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