Literature DB >> 25348678

Enhanced chondrogenesis with upregulation of PKR using a novel hydrostatic pressure bioreactor.

Jeonghyun Kim1, Kevin Montagne, Takashi Ushida, Katsuko Furukawa.   

Abstract

In this study, we developed a novel bioreactor to load hydrostatic pressure to promote chondrogenesis of prechondrogenic ATDC5 cells in as little as 3 days. Furthermore, we showed that loading hydrostatic pressure induced the upregulation of PKR, which is known to participate in mechanotransduction in various models.

Entities:  

Keywords:  ATDC5; bioreactor; chondrogenesis; hydrostatic pressure; mechanotransduction

Mesh:

Substances:

Year:  2014        PMID: 25348678     DOI: 10.1080/09168451.2014.975184

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN: 0916-8451            Impact factor:   2.043


  2 in total

1.  Hypergravity down-regulates c-fos gene expression via ROCK/Rho-GTP and the PI3K signaling pathway in murine ATDC5 chondroprogenitor cells.

Authors:  Jeonghyun Kim; Kevin Montagne; Hidetoshi Nemoto; Takashi Ushida; Katsuko S Furukawa
Journal:  PLoS One       Date:  2017-09-27       Impact factor: 3.240

2.  Acquired contractile ability in human endometrial stromal cells by passive loading of cyclic tensile stretch.

Authors:  Jeonghyun Kim; Takashi Ushida; Kevin Montagne; Yasushi Hirota; Osamu Yoshino; Takehiro Hiraoka; Yutaka Osuga; Katsuko S Furuakwa
Journal:  Sci Rep       Date:  2020-06-02       Impact factor: 4.379

  2 in total

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