| Literature DB >> 25347945 |
Anita S Chong1, David L Perkins2.
Abstract
A new study has reported a molecular signature of T-cell-mediated rejection in human kidney transplant biopsy samples that is enriched for effector T cells, interferon-γ and macrophages. Inhibitors of T-cell activation, such as CTLA4 and PDL1, were also prominent, raising the possibility that these immunological constrains could be harnessed by therapies for treating rejection.Entities:
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Year: 2014 PMID: 25347945 PMCID: PMC4425203 DOI: 10.1038/nrneph.2014.197
Source DB: PubMed Journal: Nat Rev Nephrol ISSN: 1759-5061 Impact factor: 28.314