Viola Seravalli1, Anna Pierini2,3, Fabrizio Bianchi2,3, Sabrina Giglio4,5, Francesca L Vellucci6, Ettore Cariati1. 1. a Medical Surgical Fetal-Neonatal Department , "A. Meyer" University Children's Hospital , Florence , Italy . 2. b CNR Institute of Clinical Physiology, Unit of Environmental Epidemiology , Pisa , Italy . 3. c CNR-Tuscany Region "Gabriele Monasterio" Foundation, Unit of Epidemiology , Pisa , Italy . 4. d Department of Clinical and Experimental Biomedical Sciences , University of Florence , Florence , Italy . 5. e Medical Genetics Unit , Meyer Children's University Hospital , Florence , Italy , and. 6. f Department of Molecular and Developmental Medicine , Obstetrics and Gynecology, University of Siena , Siena , Italy.
Abstract
OBJECTIVE: To evaluate the prevalence and prenatal ultrasound detection of clubfoot in Tuscany during a period of 20 years. METHODS: This is a descriptive analysis on data from the Tuscan register of congenital defects, covering a 20-year period from 1992 to 2011. The Tuscan registry of congenital defects is a population-based register for the epidemiologic surveillance of congenital anomalies. The study included all cases of pre- or postnatally diagnosed clubfoot (isolated clubfoot and cases associated with other congenital defects). Overall prevalence and pre-natal detection rates were calculated. RESULTS: Among the 549,931 deliveries recorded in Tuscany between 1992 and 2011, 858 cases of clubfoot were registered, with a prevalence of 1.56/1000. Seventy-eight percent of cases were isolated. The detection rate was higher when the defect was associated with other anomalies compared to isolated forms. Over the study period, there was a substantial improvement in the prenatal detection of clubfoot (from 11 to 31% overall). For isolated forms, detection rate improved from 4 to 16%, and for cases associated with other congenital defects, it increased from 43 to 73%. CONCLUSION: Prevalence of clubfoot in Tuscany is 1.56 per 1000 births, in agreement with the incidence reported in epidemiological studies in Europe. Prenatal detection of clubfoot improved over time. The detection rate was higher in cases associated with other anomalies.
OBJECTIVE: To evaluate the prevalence and prenatal ultrasound detection of clubfoot in Tuscany during a period of 20 years. METHODS: This is a descriptive analysis on data from the Tuscan register of congenital defects, covering a 20-year period from 1992 to 2011. The Tuscan registry of congenital defects is a population-based register for the epidemiologic surveillance of congenital anomalies. The study included all cases of pre- or postnatally diagnosed clubfoot (isolated clubfoot and cases associated with other congenital defects). Overall prevalence and pre-natal detection rates were calculated. RESULTS: Among the 549,931 deliveries recorded in Tuscany between 1992 and 2011, 858 cases of clubfoot were registered, with a prevalence of 1.56/1000. Seventy-eight percent of cases were isolated. The detection rate was higher when the defect was associated with other anomalies compared to isolated forms. Over the study period, there was a substantial improvement in the prenatal detection of clubfoot (from 11 to 31% overall). For isolated forms, detection rate improved from 4 to 16%, and for cases associated with other congenital defects, it increased from 43 to 73%. CONCLUSION: Prevalence of clubfoot in Tuscany is 1.56 per 1000 births, in agreement with the incidence reported in epidemiological studies in Europe. Prenatal detection of clubfoot improved over time. The detection rate was higher in cases associated with other anomalies.
Authors: Laura Ruzzini; Sergio De Salvatore; Umile Giuseppe Longo; Martina Marino; Alessandra Greco; Ilaria Piergentili; Pier Francesco Costici; Vincenzo Denaro Journal: Diagnostics (Basel) Date: 2021-11-29