Literature DB >> 25347137

A general approach for the development of fluorogenic probes suitable for no-wash imaging of kinases in live cells.

Qing Zhang1, Hui Liu, Zhengying Pan.   

Abstract

A general approach is presented for developing small molecule-based fluorogenic probes suitable for no-wash imaging of endogenous kinases in live cells. Probe 1, including a fluorophore-quencher system, was only "turned on" upon reacting with its target kinase Btk, and disclosed Btk's cellular location in live cells without any washing.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25347137     DOI： 10.1039/c4cc07429g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

Review 1.  Enzyme-Activated Fluorogenic Probes for Live-Cell and in Vivo Imaging.

Authors:  Wen Chyan; Ronald T Raines
Journal:  ACS Chem Biol       Date:  2018-07-06       Impact factor: 5.100

2.  Optimized Near-IR Fluorescent Agents for in Vivo Imaging of Btk Expression.

Authors:  Eunha Kim; Katherine S Yang; Rainer H Kohler; John M Dubach; Hannes Mikula; Ralph Weissleder
Journal:  Bioconjug Chem       Date:  2015-06-09       Impact factor: 4.774

3.  Drug repurposing: Ibrutinib exhibits immunosuppressive potential in organ transplantation.

Authors:  Qing Zhang; Jicheng Chen; Hanchao Gao; Song Zhang; Chengjiang Zhao; Cuibing Zhou; Chengjun Wang; Yang Li; Zhiming Cai; Lisha Mou
Journal:  Int J Med Sci       Date:  2018-07-13       Impact factor: 3.738

4.  Site-Specific Labeling of Endogenous Proteins Using CoLDR Chemistry.

Authors:  Rambabu N Reddi; Adi Rogel; Efrat Resnick; Ronen Gabizon; Pragati Kishore Prasad; Neta Gurwicz; Haim Barr; Ziv Shulman; Nir London
Journal:  J Am Chem Soc       Date:  2021-11-24       Impact factor: 15.419

5.  A novel 2,5-diaminopyrimidine-based affinity probe for Bruton's tyrosine kinase.

Authors:  Yingying Zuo; Yanxia Shi; Xitao Li; Yingqi Teng; Zhengying Pan
Journal:  Sci Rep       Date:  2015-11-04       Impact factor: 4.379
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.