Literature DB >> 25347124

A novel chimeric amine dehydrogenase shows altered substrate specificity compared to its parent enzymes.

Bettina R Bommarius1, Martin Schürmann, Andreas S Bommarius.   

Abstract

We created a novel chimeric amine dehydrogenase (AmDH) via domain shuffling of two parent AmDHs ('L- and F-AmDH'), which in turn had been generated from leucine and phenylalanine DH, respectively. Unlike the parent proteins, the chimeric AmDH ('cFL-AmDH') catalyzes the amination of acetophenone to (R)-methylbenzylamine and adamantylmethylketone to adamantylethylamine.

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Year:  2014        PMID： 25347124     DOI： 10.1039/c4cc06527a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  12 in total

Review 1.  Recent advances in imine reductase-catalyzed reactions.

Authors:  Maike Lenz; Niels Borlinghaus; Leonie Weinmann; Bettina M Nestl
Journal:  World J Microbiol Biotechnol       Date:  2017-10-11       Impact factor: 3.312

2.  In vitro biocatalytic pathway design: orthogonal network for the quantitative and stereospecific amination of alcohols.

Authors:  Tanja Knaus; Luca Cariati; Marcelo F Masman; Francesco G Mutti
Journal:  Org Biomol Chem       Date:  2017-10-11       Impact factor: 3.876

3.  Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds.

Authors:  Tanja Knaus; Wesley Böhmer; Francesco G Mutti
Journal:  Green Chem       Date:  2017-01-21       Impact factor: 10.182

4.  One-Pot Synthesis of Chiral N-Arylamines by Combining Biocatalytic Aminations with Buchwald-Hartwig N-Arylation.

Authors:  Sebastian C Cosgrove; Matthew P Thompson; Syed T Ahmed; Fabio Parmeggiani; Nicholas J Turner
Journal:  Angew Chem Int Ed Engl       Date:  2020-08-11       Impact factor: 15.336

5.  Biocatalytic hydrogen-borrowing cascades.

Authors:  Tanja Knaus; Francesco G Mutti
Journal:  Chim Oggi       Date:  2017 Sep/Oct

6.  Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades.

Authors:  Francesco G Mutti; Tanja Knaus; Nigel S Scrutton; Michael Breuer; Nicholas J Turner
Journal:  Science       Date:  2015-09-25       Impact factor: 47.728

7.  Hydrogen-Borrowing Alcohol Bioamination with Coimmobilized Dehydrogenases.

Authors:  Wesley Böhmer; Tanja Knaus; Francesco G Mutti
Journal:  ChemCatChem       Date:  2018-01-11       Impact factor: 5.686

8.  Providing reducing power by microalgal photosynthesis: a novel perspective towards sustainable biocatalytic production of bulk chemicals exemplified for aliphatic amines.

Authors:  Jana Löwe; Arthur Siewert; Anna-Catharina Scholpp; Lutz Wobbe; Harald Gröger
Journal:  Sci Rep       Date:  2018-07-11       Impact factor: 4.379

Review 9.  NAD(P)H-Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application.

Authors:  Mahima Sharma; Juan Mangas-Sanchez; Nicholas J Turner; Gideon Grogan
Journal:  Adv Synth Catal       Date:  2017-05-11       Impact factor: 5.837

10.  Mechanistic Insight into the Catalytic Promiscuity of Amine Dehydrogenases: Asymmetric Synthesis of Secondary and Primary Amines.

Authors:  Vasilis Tseliou; Marcelo F Masman; Wesley Böhmer; Tanja Knaus; Francesco G Mutti
Journal:  Chembiochem       Date:  2019-02-13       Impact factor: 3.164
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