Literature DB >> 25345807

Ubiquitin-mediated NFκB degradation pathway.

Huimin Xu, Mengli You, Haifeng Shi, Yongzhong Hou.   

Abstract

The nuclear factor κB (NFκB) transcription factor plays critical roles in inflammation and immunity. The dysregulation of NFκB is associated with inflammatory and autoimmune diseases and cancer. NFκB activation is negatively regulated by the ubiquitin-dependent proteasomal degradation pathway. In the present review, we discuss recent advances in our understanding of how ubiquitin ligases regulate the NFκB degradation pathway.

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Year:  2014        PMID： 25345807      PMCID： PMC4716629          DOI： 10.1038/cmi.2014.99

Source DB:  PubMed          Journal:  Cell Mol Immunol        ISSN： 1672-7681            Impact factor:   11.530


  30 in total

1.  Inhibitor of growth-4 promotes IkappaB promoter activation to suppress NF-kappaB signaling and innate immunity.

Authors:  Andrew H Coles; Hugh Gannon; Anna Cerny; Evelyn Kurt-Jones; Stephen N Jones
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-07       Impact factor: 11.205

2.  Inhibitor of growth 4 induces NFκB/p65 ubiquitin-dependent degradation.

Authors:  Y Hou; Z Zhang; Q Xu; H Wang; Y Xu; K Chen
Journal:  Oncogene       Date:  2013-04-29       Impact factor: 9.867

3.  Entamoeba histolytica cysteine proteinase 5 binds integrin on colonic cells and stimulates NFkappaB-mediated pro-inflammatory responses.

Authors:  Yongzhong Hou; Leanne Mortimer; Kris Chadee
Journal:  J Biol Chem       Date:  2010-09-13       Impact factor: 5.157

4.  PPARγ is an E3 ligase that induces the degradation of NFκB/p65.

Authors:  Yongzhong Hou; France Moreau; Kris Chadee
Journal:  Nat Commun       Date:  2012       Impact factor: 14.919

5.  PPARγ E3 ubiquitin ligase regulates MUC1-C oncoprotein stability.

Authors:  Y Hou; J Gao; H Xu; Y Xu; Z Zhang; Q Xu; C Zhang
Journal:  Oncogene       Date:  2013-12-02       Impact factor: 9.867

6.  Tumor necrosis factor-alpha induces RelA degradation via ubiquitination at lysine 195 to prevent excessive nuclear factor-kappaB activation.

Authors:  Yihui Fan; Renfang Mao; Yanling Zhao; Yang Yu; Wenjing Sun; Ping Song; Zhongcheng Shi; Dekai Zhang; Eric Yvon; Hong Zhang; Songbin Fu; Jianhua Yang
Journal:  J Biol Chem       Date:  2009-08-25       Impact factor: 5.157

Review 7.  PPARγ against tumors by different signaling pathways.

Authors:  Zhi Zhang; Ying Xu; Qinggang Xu; Yongzhong Hou
Journal:  Onkologie       Date:  2013-09-17

8.  The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.

Authors:  Igor Garkavtsev; Sergey V Kozin; Olga Chernova; Lei Xu; Frank Winkler; Edward Brown; Gene H Barnett; Rakesh K Jain
Journal:  Nature       Date:  2004-03-18       Impact factor: 49.962

Review 9.  Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation.

Authors:  G Solinas; G Germano; A Mantovani; P Allavena
Journal:  J Leukoc Biol       Date:  2009-09-09       Impact factor: 4.962

10.  Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase.

Authors:  Lénia Rodrigues; Josina Filipe; Mark P Seldon; Lidia Fonseca; Josef Anrather; Miguel P Soares; J Pedro Simas
Journal:  EMBO J       Date:  2009-03-26       Impact factor: 11.598
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  16 in total

Review 1.  Cellular and molecular regulation of innate inflammatory responses.

Authors:  Juan Liu; Xuetao Cao
Journal:  Cell Mol Immunol       Date:  2016-10-31       Impact factor: 11.530

Review 2.  TRIMs: selective recruitment at different steps of the NF-κB pathway-determinant of activation or resolution of inflammation.

Authors:  Milton Roy; Rajesh Singh
Journal:  Cell Mol Life Sci       Date:  2021-07-20       Impact factor: 9.261

3.  Protein-Binding Function of RNA-Dependent Protein Kinase Promotes Proliferation through TRAF2/RIP1/NF-κB/c-Myc Pathway in Pancreatic β cells.

Authors:  Lili Gao; Wei Tang; ZhengZheng Ding; DingYu Wang; XiaoQiang Qi; HuiWen Wu; Jun Guo
Journal:  Mol Med       Date:  2015-02-18       Impact factor: 6.354

4.  SMAD-specific E3 ubiquitin ligase 2 promotes angiogenesis by facilitating PTX3 degradation in MSCs from patients with ankylosing spondylitis.

Authors:  Mengjun Ma; Wen Yang; Zhaopeng Cai; Peng Wang; Hongyu Li; Rujia Mi; Yuhang Jiang; Zhongyu Xie; Pengfei Sui; Yanfeng Wu; Huiyong Shen
Journal:  Stem Cells       Date:  2021-02-06       Impact factor: 6.277

5.  Effect of Kangshuanyihao Formula on the Inflammatory Reaction and SIRT1/TLR4/NF-κB Signaling Pathway in Endothelial Injury.

Authors:  Jie Han; Hua-Qin Tong; Song-Yi Cheng; Li Yang; Han-Yu Chen; Jian-Dong Chen; Xiao-Hu Chen
Journal:  Evid Based Complement Alternat Med       Date:  2017-04-30       Impact factor: 2.629

6.  STAT3 and NF-κB are Simultaneously Suppressed in Dendritic Cells in Lung Cancer.

Authors:  Rui Li; Fang Fang; Ming Jiang; Chenguang Wang; Jiajia Ma; Wenyao Kang; Qiuyan Zhang; Yuhui Miao; Dong Wang; Yugang Guo; Linnan Zhang; Yang Guo; Hui Zhao; Zhigang Tian; Weihua Xiao
Journal:  Sci Rep       Date:  2017-03-28       Impact factor: 4.379

7.  Naoxintong/PPARγ Signaling Inhibits Cardiac Hypertrophy via Activation of Autophagy.

Authors:  Shuping Yuan; Jianhua Jin; Lu Chen; Yongzhong Hou; Hong Wang
Journal:  Evid Based Complement Alternat Med       Date:  2017-02-15       Impact factor: 2.629

Review 8.  The Ubiquitination of NF-κB Subunits in the Control of Transcription.

Authors:  Patricia E Collins; Izaskun Mitxitorena; Ruaidhrí J Carmody
Journal:  Cells       Date:  2016-05-12       Impact factor: 6.600

9.  Naoxintong/PPARα Signaling Inhibits H9c2 Cell Apoptosis and Autophagy in Response to Oxidative Stress.

Authors:  Huimin Xu; Jianhua Jin; Lu Chen; Chunxiao Li; Qinggang Xu; Juanjuan Shi; Buchang Zhao; Yongzhong Hou; Hong Wang
Journal:  Evid Based Complement Alternat Med       Date:  2016-09-07       Impact factor: 2.629

10.  Phase I/II Clinical Trial of Autologous Activated Platelet-Rich Plasma (aaPRP) in the Treatment of Severe Coronavirus Disease 2019 (COVID-19) Patients.

Authors:  Karina Karina; Iis Rosliana; Imam Rosadi; Siti Sobariah; Louis Martin Christoffel; Rita Novariani; Siti Rosidah; Novy Fatkhurohman; Yuli Hertati; Nurlaela Puspitaningrum; Wismo Reja Subroto; Irsyah Afini; Difky Ernanda
Journal:  Int J Inflam       Date:  2021-07-07
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