Vladimiro Sinay1, Manuel Perez Akly2, Gisela Zanga2, Celina Ciardi2, Juan M Racosta3. 1. Institute of Cognitive Neurology (INECO), Argentina/Institute of Neurosciences, Favaloro Foundation, Argentina vladimirosinay@gmail.com. 2. Hospital Dr César Milstein, Argentina. 3. Institute of Cognitive Neurology (INECO), Argentina/Institute of Neurosciences, Favaloro Foundation, Argentina.
Abstract
BACKGROUND: For many years, cognitive impairment has been established as a well-known symptom of multiple sclerosis. Moreover, we know that it was present even at the beginning of the disease. OBJECTIVE: In this case-control study, we decided to evaluate whether there is an impairment of cognitive functions even before onset in those patients who will eventually suffer from multiple sclerosis. METHODS: We evaluated the overall school performance, and particularly school performance in math and language in a group of patients who would later develop the disease and we compared our findings with a control group. RESULTS: We found that school performance was poorer in subjects who were to become patients. And we found that the later the start of the first symptom, the better the qualifications. CONCLUSION: Testing a premorbid cognitive deficit by a validated indirect evaluation method allowed us to verify that there was evidence of neurological compromise even before a clinical diagnosis or the completion of the first magnetic resonance imaging in patients who would then suffer from multiple sclerosis.
BACKGROUND: For many years, cognitive impairment has been established as a well-known symptom of multiple sclerosis. Moreover, we know that it was present even at the beginning of the disease. OBJECTIVE: In this case-control study, we decided to evaluate whether there is an impairment of cognitive functions even before onset in those patients who will eventually suffer from multiple sclerosis. METHODS: We evaluated the overall school performance, and particularly school performance in math and language in a group of patients who would later develop the disease and we compared our findings with a control group. RESULTS: We found that school performance was poorer in subjects who were to become patients. And we found that the later the start of the first symptom, the better the qualifications. CONCLUSION: Testing a premorbid cognitive deficit by a validated indirect evaluation method allowed us to verify that there was evidence of neurological compromise even before a clinical diagnosis or the completion of the first magnetic resonance imaging in patients who would then suffer from multiple sclerosis.
Authors: Ruth Ann Marrie; Julia O'Mahony; Colleen J Maxwell; Vicki Ling; E Ann Yeh; Douglas L Arnold; Amit Bar-Or; Brenda Banwell Journal: PLoS One Date: 2019-06-11 Impact factor: 3.240
Authors: Shashank Ghai; Elisabeth Kasilingam; Roberta Lanzillo; Masa Malenica; Vincent van Pesch; Niamh Caitlin Burke; Antonio Carotenuto; Rebecca Maguire Journal: Children (Basel) Date: 2021-05-25
Authors: João J Cerqueira; D Alastair S Compston; Ruth Geraldes; Mario M Rosa; Klaus Schmierer; Alan Thompson; Michela Tinelli; Jacqueline Palace Journal: J Neurol Neurosurg Psychiatry Date: 2018-04-04 Impact factor: 10.154