Fabio Fabbian1, Alfredo De Giorgi2, Marcello Monesi3, Marco Pala2, Ruana Tiseo2, Elisa Misurati2, Claudia Parisi2, Riccardo Volpi4, Roberto Graziani3, Dimitri P Mikhailidis5, Roberto Manfredini2. 1. Operative Unit of Clinica Medica, Department of Medical Sciences, University Hospital St. Anna, Ferrara, Italy f.fabbian@ospfe.it. 2. Operative Unit of Clinica Medica, Department of Medical Sciences, University Hospital St. Anna, Ferrara, Italy. 3. Diabetes and Clinical Nutrition, University Hospital St. Anna, Ferrara, Italy. 4. Department of Internal Medicine and Biomedical Science, University of Parma, Parma, Italy. 5. Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), University College London Medical School, University College London (UCL), London, UK.
Abstract
BACKGROUND: We investigated the relationship between serum creatinine (SCr) and estimated glomerular filtration rate (eGFR), evaluated by different formulae, and all-cause mortality (ACM) in type 2 diabetes mellitus (T2DM) outpatients. METHODS: This observational cohort study considered 1365 T2DM outpatients, who had been followed up for a period of up to 11 years. eGFR was estimated using several equations. RESULTS: Seventy subjects (5.1%) died after a follow-up of 9.8 ± 3 years. Univariate analysis showed that diagnosis of nephropathy (odds ratio (OR): 2.554, 95% confidence interval (CI): 1.616-4.038, p < 0.001) and microvascular complications (OR: 2.281, 95% CI: 1.449-3.593, p < 0.001) were associated with ACM. Receiving operating characteristic (ROC) curves showed that the areas under the curve for ACM were similar using the different eGFR equations. eGFR values were predictors of ACM, and the hazard ratios (HRs) of the different equations for eGFR estimation were similar. CONCLUSION: In our cohort of T2DM outpatients, different eGFR equations perform similarly in predicting ACM, whereas SCr did not.
BACKGROUND: We investigated the relationship between serum creatinine (SCr) and estimated glomerular filtration rate (eGFR), evaluated by different formulae, and all-cause mortality (ACM) in type 2 diabetes mellitus (T2DM) outpatients. METHODS: This observational cohort study considered 1365 T2DM outpatients, who had been followed up for a period of up to 11 years. eGFR was estimated using several equations. RESULTS: Seventy subjects (5.1%) died after a follow-up of 9.8 ± 3 years. Univariate analysis showed that diagnosis of nephropathy (odds ratio (OR): 2.554, 95% confidence interval (CI): 1.616-4.038, p < 0.001) and microvascular complications (OR: 2.281, 95% CI: 1.449-3.593, p < 0.001) were associated with ACM. Receiving operating characteristic (ROC) curves showed that the areas under the curve for ACM were similar using the different eGFR equations. eGFR values were predictors of ACM, and the hazard ratios (HRs) of the different equations for eGFR estimation were similar. CONCLUSION: In our cohort of T2DM outpatients, different eGFR equations perform similarly in predicting ACM, whereas SCr did not.
Authors: Joyce B Foryoung; Chobufo Ditah; Peter Nde Fon; Yannick Mboue-Djieka; Daniel N Nebongo; Noel D Mbango; Vanessa Balla; Simeon-Pierre Choukem Journal: BMJ Open Date: 2018-02-22 Impact factor: 2.692