Literature DB >> 25343314

p-Toluenesulfonic acid mediated 1,3-dipolar cycloaddition of nitroolefins with NaN3 for synthesis of 4-aryl-NH-1,2,3-triazoles.

Xue-Jing Quan1, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan.   

Abstract

A p-TsOH-mediated 1,3-dipolar cycloaddition of nitroolefins and sodium azide for the synthesis of 4-aryl-NH-1,2,3-triazoles has been developed. p-TsOH was discovered as a vital additive in this type of 1,3-dipolar cycloaddition. This novel cycloaddition reaction is a good method for the rapid synthesis of valuable 4-aryl-NH-1,2,3-triazoles in high yields.

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Year:  2014        PMID： 25343314     DOI： 10.1021/ol5027975

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

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2.  Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

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3.  Assembly of fully substituted triazolochromenes via a novel multicomponent reaction or mechanochemical synthesis.

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Journal:  Beilstein J Org Chem       Date:  2018-10-22       Impact factor: 2.883

4.  Copper-Catalyzed Azide-Alkyne Cycloaddition of Hydrazoic Acid Formed In Situ from Sodium Azide Affords 4-Monosubstituted-1,2,3-Triazoles.

Authors:  Dominik Jankovič; Miha Virant; Martin Gazvoda
Journal:  J Org Chem       Date:  2022-02-11       Impact factor: 4.354

5.  A green metal-free "one-pot" microwave assisted synthesis of 1,4-dihydrochromene triazoles.

Authors:  Tânia M F Alves; Guilherme A M Jardim; Marco A B Ferreira
Journal:  RSC Adv       Date:  2021-03-09       Impact factor: 3.361

6.  Metal-free, room temperature, acid-K2S2O8 mediated method for the nitration of olefins: an easy approach for the synthesis of nitroolefins.

Authors:  Srinivas Ambala; Rohit Singh; Maninder Singh; Pankaj Singh Cham; Ria Gupta; Gurunadham Munagala; Kushalava Reddy Yempalla; Ram A Vishwakarma; Parvinder Pal Singh
Journal:  RSC Adv       Date:  2019-09-25       Impact factor: 4.036
  6 in total

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