Microwave-promoted, metal- and catalyst-free decarboxylative α,β-difunctionlization of secondary α-amino acids via pseudo-four-component reactions.

A microwave-promoted, metal- and catalyst-free decarboxylative α,β-difunctionlization of secondary α-amino acids via a pseudo-four-component coupling of proline, aldehyde, and 1,3-diketone to generate multifunctionalized pyrano[2,3-b]pyrrole and pyrrolizinone derivatives is reported.