Literature DB >> 25343081

Dry age-related macular degeneration: A currently unmet clinical need.

Jean-François Girmens1, José-Alain Sahel2, Katia Marazova3.   

Abstract

Age-related macular degeneration (AMD) is a leading cause of severe visual impairment and disability in older people worldwide. Although considerable advances in the management of the neovascular form of AMD have been made in the last decade, no therapy is yet available for the advanced dry form of AMD (geographic atrophy). This review focuses on current trends in the development of new therapies targeting specific pathophysiological pathways of dry AMD. Increased understanding of the complex mechanisms that underlie dry AMD will help to address this largely unmet clinical need.

Entities:  

Keywords:  Age-related macular degeneration; clinical trials; degeneration; dry age-related macular; geographic atrophy; treatment

Year:  2012        PMID： 25343081      PMCID： PMC4204600          DOI： 10.5582/irdr.2012.v1.3.103

Source DB:  PubMed          Journal:  Intractable Rare Dis Res        ISSN： 2186-3644


  76 in total

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Journal:  Am J Hum Genet       Date:  2005-07-26       Impact factor: 11.025

2.  Selective retina therapy (SRT) in patients with geographic atrophy due to age-related macular degeneration.

Authors:  Philipp Prahs; Andreas Walter; Roman Regler; Dirk Theisen-Kunde; Reginald Birngruber; Ralf Brinkmann; Carsten Framme
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3.  Complement factor H polymorphism and age-related macular degeneration.

Authors:  Albert O Edwards; Robert Ritter; Kenneth J Abel; Alisa Manning; Carolien Panhuysen; Lindsay A Farrer
Journal:  Science       Date:  2005-03-10       Impact factor: 47.728

4.  Complement factor H variant increases the risk of age-related macular degeneration.

Authors:  Jonathan L Haines; Michael A Hauser; Silke Schmidt; William K Scott; Lana M Olson; Paul Gallins; Kylee L Spencer; Shu Ying Kwan; Maher Noureddine; John R Gilbert; Nathalie Schnetz-Boutaud; Anita Agarwal; Eric A Postel; Margaret A Pericak-Vance
Journal:  Science       Date:  2005-03-10       Impact factor: 47.728

Review 5.  Current concepts in the pathogenesis of age-related macular degeneration.

Authors:  Marco A Zarbin
Journal:  Arch Ophthalmol       Date:  2004-04

Review 6.  A role for local inflammation in the formation of drusen in the aging eye.

Authors:  Don H Anderson; Robert F Mullins; Gregory S Hageman; Lincoln V Johnson
Journal:  Am J Ophthalmol       Date:  2002-09       Impact factor: 5.258

7.  Early age-related maculopathy in the cardiovascular health study.

Authors:  Ronald Klein; Barbara E K Klein; Emily K Marino; Lewis H Kuller; Curt Furberg; Gregory L Burke; Larry D Hubbard
Journal:  Ophthalmology       Date:  2003-01       Impact factor: 12.079

8.  Retinopathy in mice induced by disrupted all-trans-retinal clearance.

Authors:  Akiko Maeda; Tadao Maeda; Marcin Golczak; Krzysztof Palczewski
Journal:  J Biol Chem       Date:  2008-07-25       Impact factor: 5.157

9.  Viewing ageing eyes: diverse sites of amyloid Beta accumulation in the ageing mouse retina and the up-regulation of macrophages.

Authors:  Jaimie Hoh Kam; Eva Lenassi; Glen Jeffery
Journal:  PLoS One       Date:  2010-10-01       Impact factor: 3.240

10.  Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice.

Authors:  Masashi Fujihara; Norihiro Nagai; Thomas E Sussan; Shyam Biswal; James T Handa
Journal:  PLoS One       Date:  2008-09-01       Impact factor: 3.240
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  13 in total

1.  NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage.

Authors:  Wenjun Xiong; Alexandra E MacColl Garfinkel; Yiqing Li; Larry I Benowitz; Constance L Cepko
Journal:  J Clin Invest       Date:  2015-03-23       Impact factor: 14.808

Review 2.  Principles of pharmacology in the eye.

Authors:  Sahar Awwad; Abeer H A Mohamed Ahmed; Garima Sharma; Jacob S Heng; Peng T Khaw; Steve Brocchini; Alastair Lockwood
Journal:  Br J Pharmacol       Date:  2017-10-10       Impact factor: 8.739

Review 3.  Aflibercept: a review of its use in the treatment of choroidal neovascularization due to age-related macular degeneration.

Authors:  Chandrakumar Balaratnasingam; Elona Dhrami-Gavazi; Jesse T McCann; Quraish Ghadiali; K Bailey Freund
Journal:  Clin Ophthalmol       Date:  2015-12-17

4.  Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival.

Authors:  Yuichi Saito; Yoshiki Kuse; Yuki Inoue; Shinsuke Nakamura; Hideaki Hara; Masamitsu Shimazawa
Journal:  Redox Biol       Date:  2018-09-05       Impact factor: 11.799

5.  Application of a Glucose Dehydrogenase-Fused with Zinc Finger Protein to Label DNA Aptamers for the Electrochemical Detection of VEGF.

Authors:  Jinhee Lee; Atsuro Tatsumi; Kaori Tsukakoshi; Ellie D Wilson; Koichi Abe; Koji Sode; Kazunori Ikebukuro
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6.  Correlation between Visual Functions and Retinal Morphology in Eyes with Early and Intermediate Age-Related Macular Degeneration.

Authors:  Rituparna Ghoshal; Sharanjeet Sharanjeet-Kaur; Norliza Mohamad Fadzil; Haliza Abdul Mutalib; Somnath Ghosh; Nor Fariza Ngah; Roslin Azni Abd Aziz
Journal:  Int J Environ Res Public Health       Date:  2020-09-02       Impact factor: 3.390

Review 7.  Nitroxide pharmaceutical development for age-related degeneration and disease.

Authors:  Jacob A Zarling; Vienna E Brunt; Anne K Vallerga; Weixing Li; Albert Tao; David A Zarling; Christopher T Minson
Journal:  Front Genet       Date:  2015-11-06       Impact factor: 4.599

8.  Plasma Exosomes Contribute to Microvascular Damage in Diabetic Retinopathy by Activating the Classical Complement Pathway.

Authors:  Chao Huang; Kiera P Fisher; Sandra S Hammer; Svetlana Navitskaya; Gary J Blanchard; Julia V Busik
Journal:  Diabetes       Date:  2018-06-04       Impact factor: 9.461

9.  Oxidative Stress-Induced Pentraxin 3 Expression Human Retinal Pigment Epithelial Cells is Involved in the Pathogenesis of Age-Related Macular Degeneration.

Authors:  Narae Hwang; Min-Young Kwon; Je Moon Woo; Su Wol Chung
Journal:  Int J Mol Sci       Date:  2019-11-29       Impact factor: 5.923

Review 10.  A Re-Appraisal of Pathogenic Mechanisms Bridging Wet and Dry Age-Related Macular Degeneration Leads to Reconsider a Role for Phytochemicals.

Authors:  Roberto Pinelli; Francesca Biagioni; Fiona Limanaqi; Miorica Bertelli; Elena Scaffidi; Maico Polzella; Carla Letizia Busceti; Francesco Fornai
Journal:  Int J Mol Sci       Date:  2020-08-03       Impact factor: 5.923
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