Literature DB >> 25341731

Interleukin 1 receptor-associated kinase 1 (IRAK1) mutation is a common, essential driver for Kaposi sarcoma herpesvirus lymphoma.

Dongmei Yang1, Wuguo Chen1, Jie Xiong2, Carly J Sherrod1, David H Henry3, Dirk P Dittmer4.   

Abstract

Primary effusion lymphoma (PEL) is an AIDS-defining cancer. All PELs carry Kaposi sarcoma-associated herpesvirus (KSHV). X chromosome-targeted sequencing of PEL identified 34 common missense mutations in 100% of cases. This included a Phe196Ser change in the interleukin 1 receptor-associated kinase 1 (IRAK1). The mutation was verified in primary PEL exudates. IRAK1 is the binding partner of MyD88, which is mutated in a fraction of Waldenström macroglobulinemia. Together, these two mediate toll-like receptor (TLR) signaling. IRAK1 was constitutively phosphorylated in PEL and required for survival, implicating IRAK1 and TLR signaling as a driver pathway in PEL and as a new drug development target.

Entities:  

Keywords:  IRAK; Kaposi sarcoma; herpesviruses; myd88; primary effusion lymphoma

Mesh：

Substances：

Year:  2014        PMID： 25341731      PMCID： PMC4226132          DOI： 10.1073/pnas.1405423111

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  36 in total

1.  Recurrent genomic imbalances in primary effusion lymphomas.

Authors:  Prakash Nair; Hongyi Pan; Raymond L Stallings; Shou-Jiang Gao
Journal:  Cancer Genet Cytogenet       Date:  2006-12

2.  Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association.

Authors:  Wen Fan; Darya Bubman; Amy Chadburn; William J Harrington; Ethel Cesarman; Daniel M Knowles
Journal:  J Virol       Date:  2005-01       Impact factor: 5.103

3.  Genetic characterization of HHV-8/KSHV-positive primary effusion lymphoma reveals frequent mutations of BCL6: implications for disease pathogenesis and histogenesis.

Authors:  G Gaidano; D Capello; A M Cilia; A Gloghini; T Perin; S Quattrone; A Migliazza; F Lo Coco; G Saglio; V Ascoli; A Carbone
Journal:  Genes Chromosomes Cancer       Date:  1999-01       Impact factor: 5.006

4.  Establishing a KSHV+ cell line (BCP-1) from peripheral blood and characterizing its growth in Nod/SCID mice.

Authors:  C Boshoff; S J Gao; L E Healy; S Matthews; A J Thomas; L Coignet; R A Warnke; J A Strauchen; E Matutes; O W Kamel; P S Moore; R A Weiss; Y Chang
Journal:  Blood       Date:  1998-03-01       Impact factor: 22.113

5.  Involvement of interleukin-10 (IL-10) and viral IL-6 in the spontaneous growth of Kaposi's sarcoma herpesvirus-associated infected primary effusion lymphoma cells.

Authors:  K D Jones; Y Aoki; Y Chang; P S Moore; R Yarchoan; G Tosato
Journal:  Blood       Date:  1999-10-15       Impact factor: 22.113

6.  Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas.

Authors:  E Cesarman; Y Chang; P S Moore; J W Said; D M Knowles
Journal:  N Engl J Med       Date:  1995-05-04       Impact factor: 91.245

7.  Gene alteration and precursor and mature microRNA transcription changes contribute to the miRNA signature of primary effusion lymphoma.

Authors:  Andrea J O'Hara; Wolfgang Vahrson; Dirk P Dittmer
Journal:  Blood       Date:  2007-12-13       Impact factor: 22.113

8.  IRAK: a kinase associated with the interleukin-1 receptor.

Authors:  Z Cao; W J Henzel; X Gao
Journal:  Science       Date:  1996-02-23       Impact factor: 47.728

9.  HHV-8-associated Kaposi sarcoma in a child with IFNgammaR1 deficiency.

Authors:  Yildiz Camcioglu; Capucine Picard; Vincent Lacoste; Stéphanie Dupuis; Necla Akçakaya; Haluk Cokura; Gültekin Kaner; Cuyan Demirkesen; Sabine Plancoulaine; Jean-François Emile; Antoine Gessain; Jean-Laurent Casanova
Journal:  J Pediatr       Date:  2004-04       Impact factor: 4.406

10.  Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling.

Authors:  Christian Kollewe; Anne-Christin Mackensen; Detlef Neumann; Johannes Knop; Ping Cao; Shyun Li; Holger Wesche; Michael U Martin
Journal:  J Biol Chem       Date:  2003-11-18       Impact factor: 5.157
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  21 in total

1.  NF-κB signaling dynamics is controlled by a dose-sensing autoregulatory loop.

Authors:  Mialy M DeFelice; Helen R Clark; Jacob J Hughey; Inbal Maayan; Takamasa Kudo; Miriam V Gutschow; Markus W Covert; Sergi Regot
Journal:  Sci Signal       Date:  2019-04-30       Impact factor: 8.192

Review 2.  Kaposi sarcoma-associated herpesvirus: immunobiology, oncogenesis, and therapy.

Authors:  Dirk P Dittmer; Blossom Damania
Journal:  J Clin Invest       Date:  2016-09-01       Impact factor: 14.808

3.  Interleukin-1 Receptor-Associated Kinase (IRAK) Signaling in Kaposi Sarcoma-Associated Herpesvirus-Induced Primary Effusion Lymphoma.

Authors:  Jedediah Seltzer; Razia Moorad; Jason M Schifano; Justin T Landis; Dirk P Dittmer
Journal:  J Virol       Date:  2020-05-04       Impact factor: 5.103

4.  Genetic variant of IRAK2 in the toll-like receptor signaling pathway and survival of non-small cell lung cancer.

Authors:  Yinghui Xu; Hongliang Liu; Shun Liu; Yanru Wang; Jichun Xie; Thomas E Stinchcombe; Li Su; Ruyang Zhang; David C Christiani; Wei Li; Qingyi Wei
Journal:  Int J Cancer       Date:  2018-09-21       Impact factor: 7.396

5.  Targeting Myddosome Signaling in Waldenström's Macroglobulinemia with the Interleukin-1 Receptor-Associated Kinase 1/4 Inhibitor R191.

Authors:  Haiwen Ni; Fazal Shirazi; Veerabhadran Baladandayuthapani; Heather Lin; Isere Kuiatse; Hua Wang; Richard J Jones; Zuzana Berkova; Yasumichi Hitoshi; Stephen M Ansell; Steven P Treon; Sheeba K Thomas; Hans C Lee; Zhiqiang Wang; R Eric Davis; Robert Z Orlowski
Journal:  Clin Cancer Res       Date:  2018-08-20       Impact factor: 12.531

6.  Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type-Specific Differences.

Authors:  Yasin Kaymaz; Cliff I Oduor; Hongbo Yu; Juliana A Otieno; John Michael Ong'echa; Ann M Moormann; Jeffrey A Bailey
Journal:  Mol Cancer Res       Date:  2017-05       Impact factor: 5.852

7.  The study of homology between tumor progression genes and members of retroviridae as a tool to predict target-directed therapy failure.

Authors:  Janaina Fernandes
Journal:  Front Pharmacol       Date:  2015-05-01       Impact factor: 5.810

8.  Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes.

Authors:  Mona M Hosseini; Stephen E Kurtz; Sherif Abdelhamed; Shawn Mahmood; Monika A Davare; Andy Kaempf; Johannes Elferich; Jason E McDermott; Tao Liu; Samuel H Payne; Ujwal Shinde; Karin D Rodland; Motomi Mori; Brian J Druker; Jack W Singer; Anupriya Agarwal
Journal:  Leukemia       Date:  2018-03-29       Impact factor: 11.528

9.  KSHV Latency Locus Cooperates with Myc to Drive Lymphoma in Mice.

Authors:  Sang-Hoon Sin; Yongbaek Kim; Anthony Eason; Dirk P Dittmer
Journal:  PLoS Pathog       Date:  2015-09-01       Impact factor: 6.823

Review 10.  Next-Generation Sequencing in the Understanding of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Biology.

Authors:  Roxanne Strahan; Timsy Uppal; Subhash C Verma
Journal:  Viruses       Date:  2016-03-31       Impact factor: 5.048
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