| Literature DB >> 25341373 |
Guillaume Pierre Charles George, Federica Pisaneschi, Quang-Dé Nguyen, Eric Ofori Aboagye.
Abstract
Molecular imaging is an attractive platform for noninvasive detection and assessment of cancer. In recent years, the targeted imaging of the C-X-C chemokine receptor 4 (CXCR4), a chemokine receptor that has been associated with tumor metastasis, has become an area of intensive research. This review article focuses on positron emission tomography (PET) and aims to provide useful and critical insights into the application of PET to characterize CXCR4 expression, including the chemical, radiosynthetic, and biological requirements for PET radiotracers. This discussion is informed by a summary of the different approaches taken so far and a comparison of their clinical translation. Finally, our expert opinions as to potential future advances in the field are expressed.Entities:
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Year: 2014 PMID： 25341373 DOI： 10.2310/7290.2014.00041
Source DB: PubMed Journal: Mol Imaging ISSN： 1535-3508 Impact factor: 4.488